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10.3390/ijms22084067 http://scihub22266oqcxt.onion/10.3390/ijms22084067 33920748!8071111!33920748     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (8): ä Nephropedia Template TP {{tp|p=33920748|t=2021. Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19 |pdf=|usr=}}{{33920748}} gab.com Text Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19 JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33920748 #FOAvip The family of coronaviruses (CoVs) uses the autophagy machinery of host cells to promote their growth and replication; thus, this process stands out as a potential target to combat COVID-19. Considering the different roles of autophagy during viral infection, including SARS-CoV-2 infection, in this review, we discuss several clinically used drugs that have effects at different stages of autophagy. Among them, we mention (1) lysosomotropic agents, which can prevent CoVs infection by alkalinizing the acid pH in the endolysosomal system, such as chloroquine and hydroxychloroquine, azithromycin, artemisinins, two-pore channel modulators and imatinib; (2) protease inhibitors that can inhibit the proteolytic cleavage of the spike CoVs protein, which is necessary for viral entry into host cells, such as camostat mesylate, lopinavir, umifenovir and teicoplanin and (3) modulators of PI3K/AKT/mTOR signaling pathways, such as rapamycin, heparin, glucocorticoids, angiotensin-converting enzyme inhibitors (IECAs) and cannabidiol. Thus, this review aims to highlight and discuss autophagy-related drugs for COVID-19, from in vitro to in vivo studies. We identified specific compounds that may modulate autophagy and exhibit antiviral properties. We hope that research initiatives and efforts will identify novel or "off-label" drugs that can be used to effectively treat patients infected with SARS-CoV-2, reducing the risk of mortality. Twit Text FOAVip Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19 ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33920748 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33920748 #FOAvip English Wikipedia <ref>{{Cite pmid|33920748}}</ref> Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19 #MMPMID33920748 Pereira GJDS; Leao AHFF; Erustes AG; Morais IBM; Vrechi TAM; Zamarioli LDS; Pereira CAS; Marchioro LO; Sperandio LP; Lins IVF; Piacentini M; Fimia GM; Reckziegel P; Smaili SS; Bincoletto C Int J Mol Sci 2021[Apr]; 22 (8): ä PMID33920748show ga The family of coronaviruses (CoVs) uses the autophagy machinery of host cells to promote their growth and replication; thus, this process stands out as a potential target to combat COVID-19. Considering the different roles of autophagy during viral infection, including SARS-CoV-2 infection, in this review, we discuss several clinically used drugs that have effects at different stages of autophagy. Among them, we mention (1) lysosomotropic agents, which can prevent CoVs infection by alkalinizing the acid pH in the endolysosomal system, such as chloroquine and hydroxychloroquine, azithromycin, artemisinins, two-pore channel modulators and imatinib; (2) protease inhibitors that can inhibit the proteolytic cleavage of the spike CoVs protein, which is necessary for viral entry into host cells, such as camostat mesylate, lopinavir, umifenovir and teicoplanin and (3) modulators of PI3K/AKT/mTOR signaling pathways, such as rapamycin, heparin, glucocorticoids, angiotensin-converting enzyme inhibitors (IECAs) and cannabidiol. Thus, this review aims to highlight and discuss autophagy-related drugs for COVID-19, from in vitro to in vivo studies. We identified specific compounds that may modulate autophagy and exhibit antiviral properties. We hope that research initiatives and efforts will identify novel or "off-label" drugs that can be used to effectively treat patients infected with SARS-CoV-2, reducing the risk of mortality. |*COVID-19 Drug Treatment[MESH] |*Molecular Targeted Therapy[MESH] |Autophagy/*drug effects[MESH] |Humans[MESH] |SARS-CoV-2/drug effects/physiology[MESH] |Signal Transduction[MESH]Pharmacological Modulators of Autophagy as a Potential Strategy for th(epmc).pdf DeepDyve Pubget Overpricing