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10.3390/nu13041297 http://scihub22266oqcxt.onion/10.3390/nu13041297 33919991!8071056!33919991     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nutrients 2021 ; 13 (4): ä Nephropedia Template TP {{tp|p=33919991|t=2021. L-Carnitine Tartrate Downregulates the ACE2 Receptor and Limits SARS-CoV-2 Infection |pdf=|usr=}}{{33919991}} gab.com Text L-Carnitine Tartrate Downregulates the ACE2 Receptor and Limits SARS-CoV-2 Infection JO: Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=33919991 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for one of the worst pandemics in modern history. Several prevention and treatment strategies have been designed and evaluated in recent months either through the repurposing of existing treatments or the development of new drugs and vaccines. In this study, we show that L-carnitine tartrate supplementation in humans and rodents led to significant decreases of key host dependency factors, notably angiotensin-converting enzyme 2 (ACE2), transmembrane protease serine 2 (TMPRSS2), and Furin, which are responsible for viral attachment, viral spike S-protein cleavage, and priming for viral fusion and entry. Interestingly, pre-treatment of Calu-3, human lung epithelial cells, with L-carnitine tartrate led to a significant and dose-dependent inhibition of the infection by SARS-CoV-2. Infection inhibition coincided with a significant decrease in ACE2 mRNA expression levels. These data suggest that L-carnitine tartrate should be tested with appropriate trials in humans for the possibility to limit SARS-CoV-2 infection. Twit Text FOAVip L-Carnitine Tartrate Downregulates the ACE2 Receptor and Limits SARS-CoV-2 Infection ????Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=33919991 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33919991 #FOAvip English Wikipedia <ref>{{Cite pmid|33919991}}</ref> L-Carnitine Tartrate Downregulates the ACE2 Receptor and Limits SARS-CoV-2 Infection #MMPMID33919991 Bellamine A; Pham TNQ; Jain J; Wilson J; Sahin K; Dallaire F; Seidah NG; Durkee S; Radosevic K; Cohen EA Nutrients 2021[Apr]; 13 (4): ä PMID33919991show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for one of the worst pandemics in modern history. Several prevention and treatment strategies have been designed and evaluated in recent months either through the repurposing of existing treatments or the development of new drugs and vaccines. In this study, we show that L-carnitine tartrate supplementation in humans and rodents led to significant decreases of key host dependency factors, notably angiotensin-converting enzyme 2 (ACE2), transmembrane protease serine 2 (TMPRSS2), and Furin, which are responsible for viral attachment, viral spike S-protein cleavage, and priming for viral fusion and entry. Interestingly, pre-treatment of Calu-3, human lung epithelial cells, with L-carnitine tartrate led to a significant and dose-dependent inhibition of the infection by SARS-CoV-2. Infection inhibition coincided with a significant decrease in ACE2 mRNA expression levels. These data suggest that L-carnitine tartrate should be tested with appropriate trials in humans for the possibility to limit SARS-CoV-2 infection. |*COVID-19 Drug Treatment[MESH] |Adult[MESH] |Aged[MESH] |Angiotensin-Converting Enzyme 2/blood/*metabolism[MESH] |Animals[MESH] |COVID-19/metabolism[MESH] |Carnitine/*administration & dosage/pharmacology[MESH] |Cell Line[MESH] |Cell Survival/drug effects[MESH] |Female[MESH] |Furin/blood/metabolism[MESH] |Humans[MESH] |Inflammation/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Rats[MESH] |SARS-CoV-2[MESH] |Serine Endopeptidases/blood/metabolism[MESH] |Tartrates/*administration & dosage/pharmacology[MESH]L-Carnitine Tartrate Downregulates the ACE2 Receptor and Limits SARS-C(epmc).pdf DeepDyve Pubget Overpricing