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10.3390/v13050724

http://scihub22266oqcxt.onion/10.3390/v13050724
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33919314!8143327!33919314
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suck abstract from ncbi


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pmid33919314      Viruses 2021 ; 13 (5): ä
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  • A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B 1 1 33 Circulating in Brazil #MMPMID33919314
  • Resende PC; Graf T; Paixao ACD; Appolinario L; Lopes RS; Mendonca ACDF; da Rocha ASB; Motta FC; Neto LGL; Khouri R; de Oliveira CI; Santos-Muccillo P; Bezerra JF; Teixeira DLF; Riediger I; Debur MDC; Ribeiro-Rodrigues R; Leite AB; do Santos CA; Gregianini TS; Fernandes SB; Bernardes AFL; Cavalcanti AC; Miyajima F; Sachhi C; Mattos T; da Costa CF; Delatorre E; Wallau GL; Naveca FG; Bello G; Siqueira MM
  • Viruses 2021[Apr]; 13 (5): ä PMID33919314show ga
  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Brazil was dominated by two lineages designated as B.1.1.28 and B.1.1.33. The two SARS-CoV-2 variants harboring mutations at the receptor-binding domain of the Spike (S) protein, designated as lineages P.1 and P.2, evolved from lineage B.1.1.28 and are rapidly spreading in Brazil. Lineage P.1 is considered a Variant of Concern (VOC) because of the presence of multiple mutations in the S protein (including K417T, E484K, N501Y), while lineage P.2 only harbors mutation S:E484K and is considered a Variant of Interest (VOI). On the other hand, epidemiologically relevant B.1.1.33 deriving lineages have not been described so far. Here we report the identification of a new SARS-CoV-2 VOI within lineage B.1.1.33 that also harbors mutation S:E484K and was detected in Brazil between November 2020 and February 2021. This VOI displayed four non-synonymous lineage-defining mutations (NSP3:A1711V, NSP6:F36L, S:E484K, and NS7b:E33A) and was designated as lineage N.9. The VOI N.9 probably emerged in August 2020 and has spread across different Brazilian states from the Southeast, South, North, and Northeast regions.
  • |*Mutation[MESH]
  • |Brazil/epidemiology[MESH]
  • |COVID-19/*epidemiology/*virology[MESH]
  • |Genome, Viral[MESH]
  • |Humans[MESH]
  • |Molecular Epidemiology[MESH]
  • |Protein Binding[MESH]
  • |SARS-CoV-2/*genetics/isolation & purification[MESH]


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