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10.3390/v13040645 http://scihub22266oqcxt.onion/10.3390/v13040645 33918599!8069079!33918599     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2021 ; 13 (4): ä Nephropedia Template TP {{tp|p=33918599|t=2021. The Spike Glycoprotein of SARS-CoV-2 Binds to beta1 Integrins Expressed on the Surface of Lung Epithelial Cells |pdf=|usr=}}{{33918599}} gab.com Text The Spike Glycoprotein of SARS-CoV-2 Binds to beta1 Integrins Expressed on the Surface of Lung Epithelial Cells JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33918599 #FOAvip The spike glycoprotein attached to the envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to and exploits angiotensin-converting enzyme 2 (ACE2) as an entry receptor to infect pulmonary epithelial cells. A subset of integrins that recognize the arginyl-glycyl-aspartic acid (RGD) sequence in the cognate ligands has been predicted in silico to bind the spike glycoprotein and, thereby, to be exploited for viral infection. Here, we show experimental evidence that the beta1 integrins predominantly expressed on human pulmonary epithelial cell lines and primary mouse alveolar epithelial cells bind to this spike protein. The cellular beta1 integrins support adhesive interactions with the spike protein independently of ACE2, suggesting the possibility that the beta1 integrins may function as an alternative receptor for SARS-CoV-2, which could be targeted for the prevention of viral infections. Twit Text FOAVip The Spike Glycoprotein of SARS-CoV-2 Binds to beta1 Integrins Expressed on the Surface of Lung Epithelial Cells ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33918599 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33918599 #FOAvip English Wikipedia <ref>{{Cite pmid|33918599}}</ref> The Spike Glycoprotein of SARS-CoV-2 Binds to beta1 Integrins Expressed on the Surface of Lung Epithelial Cells #MMPMID33918599 Park EJ; Myint PK; Appiah MG; Darkwah S; Caidengbate S; Ito A; Matsuo E; Kawamoto E; Gaowa A; Shimaoka M Viruses 2021[Apr]; 13 (4): ä PMID33918599show ga The spike glycoprotein attached to the envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to and exploits angiotensin-converting enzyme 2 (ACE2) as an entry receptor to infect pulmonary epithelial cells. A subset of integrins that recognize the arginyl-glycyl-aspartic acid (RGD) sequence in the cognate ligands has been predicted in silico to bind the spike glycoprotein and, thereby, to be exploited for viral infection. Here, we show experimental evidence that the beta1 integrins predominantly expressed on human pulmonary epithelial cell lines and primary mouse alveolar epithelial cells bind to this spike protein. The cellular beta1 integrins support adhesive interactions with the spike protein independently of ACE2, suggesting the possibility that the beta1 integrins may function as an alternative receptor for SARS-CoV-2, which could be targeted for the prevention of viral infections. |Alveolar Epithelial Cells/*metabolism[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Animals[MESH] |COVID-19/virology[MESH] |Cell Adhesion[MESH] |Cell Line[MESH] |Humans[MESH] |Integrin beta1/*metabolism[MESH] |Lung/metabolism[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Oligopeptides[MESH] |Protein Binding[MESH] |Receptors, Virus/metabolism[MESH] |SARS-CoV-2/*metabolism[MESH] |Spike Glycoprotein, Coronavirus/*metabolism[MESH] |THP-1 Cells[MESH]The Spike Glycoprotein of SARS-CoV-2 Binds to beta1 Integrins Expresse(epmc).pdf DeepDyve Pubget Overpricing