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10.3390/jcm10081551

http://scihub22266oqcxt.onion/10.3390/jcm10081551
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suck abstract from ncbi


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pmid33917093      J+Clin+Med 2021 ; 10 (8): ä
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  • Use of Anti-Cytokine Therapy in Kidney Transplant Recipients with COVID-19 #MMPMID33917093
  • Bodro M; Cofan F; Rios J; Herrera S; Linares L; Marcos MA; Soriano A; Moreno A; Diekmann F
  • J Clin Med 2021[Apr]; 10 (8): ä PMID33917093show ga
  • In the context of the coronavirus disease 2019 (COVID-19) pandemic, we aimed to evaluate the impact of anti-cytokine therapies (AT) in kidney transplant recipients requiring hospitalization due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This is an observational retrospective study, which included patients from March to May 2020. An inverse probability of treatment weighting from a propensity score to receive AT was used in all statistical analyses, and we applied a bootstrap procedure in order to calculate an estimation of the 2.5th and 97.5th percentiles of odds ratio (OR). outcomes were measured using an ordinal scale determination (OSD). A total of 33 kidney recipients required hospitalization and 54% of them received at least one AT, mainly tocilizumab (42%), followed by anakinra (12%). There was no statistical effect in terms of intensive care unit (ICU) admission, respiratory secondary infections (35% vs. 7%) or mortality (16% vs. 13%) comparing patients that received AT with those who did not. Nevertheless, patients who received AT presented better outcomes during hospitalization in terms of OSD >/=5 ((OR 0.31; 2.5th, 97.5th percentiles (0.10; 0.72)). These analyses indicate, as a plausible hypothesis, that the use of AT in kidney transplant recipients presenting with COVID-19 could be beneficial, even though multicenter randomized control trials using these therapies in transplanted patients are needed.
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