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10.3390/microorganisms9040756 http://scihub22266oqcxt.onion/10.3390/microorganisms9040756 33916747!8065850!33916747     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microorganisms 2021 ; 9 (4): ä Nephropedia Template TP {{tp|p=33916747|t=2021. A Study of 3CLpros as Promising Targets against SARS-CoV and SARS-CoV-2 |pdf=|usr=}}{{33916747}} gab.com Text A Study of 3CLpros as Promising Targets against SARS-CoV and SARS-CoV-2 JO: Microorganisms http://www.kidney.de/pget.php?&tw=1&pmid=33916747 #FOAvip The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in serious chaos all over the world. In addition to the available vaccines, the development of treatments to cure COVID-19 should be done quickly. One of the fastest strategies is to use a drug-repurposing approach. To provide COVID-19 patients with useful information about medicines currently being used in clinical trials, twenty-four compounds, including antiviral agents, were selected and assayed. These compounds were applied to verify the inhibitory activity for the protein function of 3CLpros (main proteases) of SARS-CoV and SARS-CoV-2. Among them, viral reverse-transcriptase inhibitors abacavir and tenofovir revealed a good inhibitory effect on both 3CLpros. Intriguingly, sildenafil, a cGMP-specific phosphodiesterase type 5 inhibitor also showed significant inhibitory function against them. The in silico docking study suggests that the active-site residues located in the S1 and S2 sites play key roles in the interactions with the inhibitors. The result indicates that 3CLpros are promising targets to cope with SAR-CoV-2 and its variants. The information can be helpful to design treatments to cure patients with COVID-19. Twit Text FOAVip A Study of 3CLpros as Promising Targets against SARS-CoV and SARS-CoV-2 ????Microorganisms http://www.kidney.de/pget.php?&tw=1&pmid=33916747 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33916747 #FOAvip English Wikipedia <ref>{{Cite pmid|33916747}}</ref> A Study of 3CLpros as Promising Targets against SARS-CoV and SARS-CoV-2 #MMPMID33916747 Jo S; Kim S; Yoo J; Kim MS; Shin DH Microorganisms 2021[Apr]; 9 (4): ä PMID33916747show ga The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in serious chaos all over the world. In addition to the available vaccines, the development of treatments to cure COVID-19 should be done quickly. One of the fastest strategies is to use a drug-repurposing approach. To provide COVID-19 patients with useful information about medicines currently being used in clinical trials, twenty-four compounds, including antiviral agents, were selected and assayed. These compounds were applied to verify the inhibitory activity for the protein function of 3CLpros (main proteases) of SARS-CoV and SARS-CoV-2. Among them, viral reverse-transcriptase inhibitors abacavir and tenofovir revealed a good inhibitory effect on both 3CLpros. Intriguingly, sildenafil, a cGMP-specific phosphodiesterase type 5 inhibitor also showed significant inhibitory function against them. The in silico docking study suggests that the active-site residues located in the S1 and S2 sites play key roles in the interactions with the inhibitors. The result indicates that 3CLpros are promising targets to cope with SAR-CoV-2 and its variants. The information can be helpful to design treatments to cure patients with COVID-19. äA Study of 3CLpros as Promising Targets against SARS-CoV and SARS-CoV-(epmc).pdf DeepDyve Pubget Overpricing