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10.3390/jcm10071441 http://scihub22266oqcxt.onion/10.3390/jcm10071441 33916167!8037587!33916167     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Med 2021 ; 10 (7): ä Nephropedia Template TP {{tp|p=33916167|t=2021. Sex-Related Differences in Drugs with Anti-Inflammatory Properties |pdf=|usr=}}{{33916167}} gab.com Text Sex-Related Differences in Drugs with Anti-Inflammatory Properties JO: J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=33916167 #FOAvip There is increasing evidence of sex differences in the action of anti-inflammatory drugs, with women being at significantly higher risk of adverse effects. Nevertheless, clinicians' awareness of the implications of these sex differences on dosing and adverse event monitoring in routine practice is still in need of improvement. We reviewed the literature evaluating sex differences in terms of pharmacokinetics and pharmacodynamics of anti-inflammatory drugs. The anti-thrombotic activity of selective and non-selective COX-inhibitors tends to be stronger in men than women. Side effect profiles differ with regards to gastro-intestinal, renal and hepatic complications. Glucocorticosteroids were found to be more effective in men; women were more sensitive to corticosteroids when their oestradiol levels were high, a finding important for women taking hormonal contraception. TNF-alpha inhibitors have a longer half-life in men, leading to stronger immunosuppression and this a higher incidence of infections as side effects. Although research on sex differences in the effectiveness and safety of drugs is increasing, findings are often anecdotal and controversial. There is no systematic sex-differentiated reporting from clinical trials, and women are often under-represented. As personalized medicine is gaining in importance, sex, and gender aspects need to become integral parts of future research and policy making. Twit Text FOAVip Sex-Related Differences in Drugs with Anti-Inflammatory Properties ????J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=33916167 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33916167 #FOAvip English Wikipedia <ref>{{Cite pmid|33916167}}</ref> Sex-Related Differences in Drugs with Anti-Inflammatory Properties #MMPMID33916167 Farkouh A; Baumgartel C; Gottardi R; Hemetsberger M; Czejka M; Kautzky-Willer A J Clin Med 2021[Apr]; 10 (7): ä PMID33916167show ga There is increasing evidence of sex differences in the action of anti-inflammatory drugs, with women being at significantly higher risk of adverse effects. Nevertheless, clinicians' awareness of the implications of these sex differences on dosing and adverse event monitoring in routine practice is still in need of improvement. We reviewed the literature evaluating sex differences in terms of pharmacokinetics and pharmacodynamics of anti-inflammatory drugs. The anti-thrombotic activity of selective and non-selective COX-inhibitors tends to be stronger in men than women. Side effect profiles differ with regards to gastro-intestinal, renal and hepatic complications. Glucocorticosteroids were found to be more effective in men; women were more sensitive to corticosteroids when their oestradiol levels were high, a finding important for women taking hormonal contraception. TNF-alpha inhibitors have a longer half-life in men, leading to stronger immunosuppression and this a higher incidence of infections as side effects. Although research on sex differences in the effectiveness and safety of drugs is increasing, findings are often anecdotal and controversial. There is no systematic sex-differentiated reporting from clinical trials, and women are often under-represented. As personalized medicine is gaining in importance, sex, and gender aspects need to become integral parts of future research and policy making. äSex-Related Differences in Drugs with Anti-Inflammatory Properties (epmc).pdf DeepDyve Pubget Overpricing