BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19 #MMPMID33915773
Ji RR; Qu Y; Zhu H; Yang Y; Vogel AB; Sahin U; Qin C; Hui A
Vaccines (Basel) 2021[Apr]; 9 (4): ? PMID33915773show ga
BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2, which correlated with viral clearance and alleviated lung lesions in these mice after viral challenge.