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  • COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets #MMPMID33915569
  • Delorey TM; Ziegler CGK; Heimberg G; Normand R; Yang Y; Segerstolpe A; Abbondanza D; Fleming SJ; Subramanian A; Montoro DT; Jagadeesh KA; Dey KK; Sen P; Slyper M; Pita-Juarez YH; Phillips D; Biermann J; Bloom-Ackermann Z; Barkas N; Ganna A; Gomez J; Melms JC; Katsyv I; Normandin E; Naderi P; Popov YV; Raju SS; Niezen S; Tsai LT; Siddle KJ; Sud M; Tran VM; Vellarikkal SK; Wang Y; Amir-Zilberstein L; Atri DS; Beechem J; Brook OR; Chen J; Divakar P; Dorceus P; Engreitz JM; Essene A; Fitzgerald DM; Fropf R; Gazal S; Gould J; Grzyb J; Harvey T; Hecht J; Hether T; Jane-Valbuena J; Leney-Greene M; Ma H; McCabe C; McLoughlin DE; Miller EM; Muus C; Niemi M; Padera R; Pan L; Pant D; Pe'er C; Pfiffner-Borges J; Pinto CJ; Plaisted J; Reeves J; Ross M; Rudy M; Rueckert EH; Siciliano M; Sturm A; Todres E; Waghray A; Warren S; Zhang S; Zollinger DR; Cosimi L; Gupta RM; Hacohen N; Hibshoosh H; Hide W; Price AL; Rajagopal J; Tata PR; Riedel S; Szabo G; Tickle TL; Ellinor PT; Hung D; Sabeti PC; Novak R; Rogers R; Ingber DE; Jiang ZG; Juric D; Babadi M; Farhi SL; Izar B; Stone JR; Vlachos IS; Solomon IH; Ashenberg O; Porter CBM; Li B; Shalek AK; Villani AC; Rozenblatt-Rosen O; Regev A
  • Nature 2021[Jul]; 595 (7865): 107-113 PMID33915569show ga
  • COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome and multiple organ failure(1-4), but little is known about its pathophysiology. Here we generated single-cell atlases of 24 lung, 16 kidney, 16 liver and 19 heart autopsy tissue samples and spatial atlases of 14 lung samples from donors who died of COVID-19. Integrated computational analysis uncovered substantial remodelling in the lung epithelial, immune and stromal compartments, with evidence of multiple paths of failed tissue regeneration, including defective alveolar type 2 differentiation and expansion of fibroblasts and putative TP63(+) intrapulmonary basal-like progenitor cells. Viral RNAs were enriched in mononuclear phagocytic and endothelial lung cells, which induced specific host programs. Spatial analysis in lung distinguished inflammatory host responses in lung regions with and without viral RNA. Analysis of the other tissue atlases showed transcriptional alterations in multiple cell types in heart tissue from donors with COVID-19, and mapped cell types and genes implicated with disease severity based on COVID-19 genome-wide association studies. Our foundational dataset elucidates the biological effect of severe SARS-CoV-2 infection across the body, a key step towards new treatments.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Atlases as Topic[MESH]
  • |Autopsy[MESH]
  • |Biological Specimen Banks[MESH]
  • |COVID-19/genetics/immunology/*pathology/*virology[MESH]
  • |Endothelial Cells[MESH]
  • |Epithelial Cells/pathology/virology[MESH]
  • |Female[MESH]
  • |Fibroblasts[MESH]
  • |Genome-Wide Association Study[MESH]
  • |Heart/virology[MESH]
  • |Humans[MESH]
  • |Inflammation/pathology/virology[MESH]
  • |Kidney/*pathology/virology[MESH]
  • |Liver/*pathology/virology[MESH]
  • |Lung/*pathology/virology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Myocardium/*pathology[MESH]
  • |Organ Specificity[MESH]
  • |Phagocytes[MESH]
  • |Pulmonary Alveoli/pathology/virology[MESH]
  • |RNA, Viral/analysis[MESH]
  • |Regeneration[MESH]
  • |SARS-CoV-2/immunology/*pathogenicity[MESH]
  • |Single-Cell Analysis[MESH]
  • |Viral Load[MESH]

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  • suck abstract from ncbi

    107 7865.595 2021