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10.1016/j.biopha.2021.111599

http://scihub22266oqcxt.onion/10.1016/j.biopha.2021.111599
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suck abstract from ncbi


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pmid33915502      Biomed+Pharmacother 2021 ; 139 (ä): 111599
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  • Novel and emerging mutations of SARS-CoV-2: Biomedical implications #MMPMID33915502
  • Mohammadi E; Shafiee F; Shahzamani K; Ranjbar MM; Alibakhshi A; Ahangarzadeh S; Beikmohammadi L; Shariati L; Hooshmandi S; Ataei B; Javanmard SH
  • Biomed Pharmacother 2021[Jul]; 139 (ä): 111599 PMID33915502show ga
  • Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its virulence and pathogenesis. Hence, understanding these features can be used to predict the future transmission dynamics of SARS-CoV-2 infection, drug development, and vaccine. In this review, we discuss the most recent findings on the mutations in the SARS-CoV-2, which provide valuable information on the genetic diversity of SARS-CoV-2, especially for DNA-based diagnosis, antivirals, and vaccine development for COVID-19.
  • |*Mutation[MESH]
  • |COVID-19/*genetics[MESH]
  • |Genome, Viral[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2/*genetics[MESH]


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