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10.1016/j.chom.2021.04.003 http://scihub22266oqcxt.onion/10.1016/j.chom.2021.04.003 33915112!8080417!33915112     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2021 ; 29 (5): 689-703 Nephropedia Template TP {{tp|p=33915112|t=2021. Detect and destroy: CRISPR-based technologies for the response against viruses |pdf=|usr=}}{{33915112}} gab.com Text Detect and destroy: CRISPR-based technologies for the response against viruses JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=33915112 #FOAvip Despite numerous viral outbreaks in the last decade, including a devastating global pandemic, diagnostic and therapeutic technologies remain severely lacking. CRISPR-Cas systems have the potential to address these critical needs in the response against infectious disease. Initially discovered as the bacterial adaptive immune system, these systems provide a unique opportunity to create programmable, sequence-specific technologies for detection of viral nucleic acids and inhibition of viral replication. This review summarizes how CRISPR-Cas systems-in particular the recently discovered DNA-targeting Cas12 and RNA-targeting Cas13, both possessing a unique trans-cleavage activity-are being harnessed for viral diagnostics and therapies. We further highlight the numerous technologies whose development has accelerated in response to the COVID-19 pandemic. Twit Text FOAVip Detect and destroy: CRISPR-based technologies for the response against viruses ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=33915112 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33915112 #FOAvip English Wikipedia <ref>{{Cite pmid|33915112}}</ref> Detect and destroy: CRISPR-based technologies for the response against viruses #MMPMID33915112 Freije CA; Sabeti PC Cell Host Microbe 2021[May]; 29 (5): 689-703 PMID33915112show ga Despite numerous viral outbreaks in the last decade, including a devastating global pandemic, diagnostic and therapeutic technologies remain severely lacking. CRISPR-Cas systems have the potential to address these critical needs in the response against infectious disease. Initially discovered as the bacterial adaptive immune system, these systems provide a unique opportunity to create programmable, sequence-specific technologies for detection of viral nucleic acids and inhibition of viral replication. This review summarizes how CRISPR-Cas systems-in particular the recently discovered DNA-targeting Cas12 and RNA-targeting Cas13, both possessing a unique trans-cleavage activity-are being harnessed for viral diagnostics and therapies. We further highlight the numerous technologies whose development has accelerated in response to the COVID-19 pandemic. |*CRISPR-Cas Systems[MESH] |COVID-19/*diagnosis/therapy[MESH] |Humans[MESH] |Mutation[MESH] |RNA, Circular/genetics[MESH]Detect and destroy: CRISPR-based technologies for the response against(epmc).pdf DeepDyve Pubget Overpricing