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10.1371/journal.pone.0250330

http://scihub22266oqcxt.onion/10.1371/journal.pone.0250330
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33914789!8084148!33914789
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suck abstract from ncbi


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pmid33914789      PLoS+One 2021 ; 16 (4): e0250330
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  • Analysis of cytokines in SARS-CoV-2 or COVID-19 patients in Erbil city, Kurdistan Region of Iraq #MMPMID33914789
  • Merza MY; Hwaiz RA; Hamad BK; Mohammad KA; Hama HA; Karim AY
  • PLoS One 2021[]; 16 (4): e0250330 PMID33914789show ga
  • The emergence of the novel coronavirus and then pandemic outbreak was coined 2019- nCoV or COVID-19 (or SARS-CoV-2 disease 2019). This disease has a mortality rate of about 3.7 percent, and successful therapy is desperately needed to combat it. The exact cellular mechanisms of COVID-19 need to be illustrated in detail. This study aimed to evaluate serum cytokines in COVID-19 patients. In this study, serum was collected from volunteer individuals, moderate COVID-19 patients, severe cases of COVID-19 patients, and patients who recovered from COVID-19 (n = 122). The serum concentrations of interleukins such as IL-1, IL-4, IL-6, IL-8, IL-10, and tumor necrosis factor-alpha (TNF-alpha), were measured by enzyme-linked immunosorbent assays (ELISA). The concentrations of IL-1 and TNF-alpha were did not differ significantly among groups. However, the concentration of IL-6 was significantly higher in moderate COVID-19 and severe cases of COVID-19 groups compared to control and recovered groups indicating it to be an independent predictor in the coronavirus disease. The levels of IFN-gamma and IL-4 were significantly lower in the recovery group than the severe case of the COVID-19 group. In contrast, the level of IL-10 in recovered COVID-19 patients was significantly higher in compare to severe cases, COVID-19 patients. Varying levels of cytokines were detected in COVID-19 group than control group suggesting distinct immunoregulatory mechanisms involved in COVID-19 pathogenesis. However, additional investigations are needed to be to be performed to understand the exact cellular mechanism of this disease.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/*blood/epidemiology[MESH]
  • |Cytokines/*blood[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interferon-gamma/blood[MESH]
  • |Interleukin-10/blood[MESH]
  • |Interleukin-4/blood[MESH]
  • |Interleukin-6/blood[MESH]
  • |Iraq/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]
  • |Tumor Necrosis Factor-alpha/blood[MESH]


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