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10.1002/jmv.27053

http://scihub22266oqcxt.onion/10.1002/jmv.27053
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33913549!8242852!33913549
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suck abstract from ncbi


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pmid33913549      J+Med+Virol 2021 ; 93 (9): 5390-5395
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  • Decreased in-hospital mortality associated with aspirin administration in hospitalized patients due to severe COVID-19 #MMPMID33913549
  • Haji Aghajani M; Moradi O; Amini H; Azhdari Tehrani H; Pourheidar E; Rabiei MM; Sistanizad M
  • J Med Virol 2021[Sep]; 93 (9): 5390-5395 PMID33913549show ga
  • Hypercoagulability and thrombosis caused by coronavirus disease 2019 (COVID-19) are related to the higher mortality rate. Because of limited data on the antiplatelet effect, we aimed to evaluate the impact of aspirin add-on therapy on the outcome of the patients hospitalized due to severe COVID-19. In this cohort study, patients with a confirmed diagnosis of severe COVID-19 admitted to Imam Hossein Medical Center, Tehran, Iran from March 2019 to July 2020 were included. Demographics and related clinical data during their hospitalization were recorded. The mortality rate of the patients was considered as the primary outcome and its association with aspirin use was assessed. Nine hundred and ninety-one patients were included, of that 336 patients (34%) received aspirin during their hospitalization and 655 ones (66%) did not. Comorbidities were more prevalent in the patients who were receiving aspirin. Results from the multivariate COX proportional model demonstrated a significant independent association between aspirin use and reduction in the risk of in-hospital mortality (0.746 [0.560-0.994], p = 0.046). Aspirin use in hospitalized patients with COVID-19 is associated with a significant decrease in mortality rate. Further prospective randomized controlled trials are needed to assess the efficacy and adverse effects of aspirin administration in this population.
  • |*COVID-19 Drug Treatment[MESH]
  • |Adenosine Monophosphate/analogs & derivatives/therapeutic use[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Alanine/analogs & derivatives/therapeutic use[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Aspirin/*therapeutic use[MESH]
  • |Blood Platelets/drug effects/pathology/virology[MESH]
  • |COVID-19/complications/mortality/virology[MESH]
  • |Coronary Artery Disease/complications/drug therapy/mortality/virology[MESH]
  • |Diabetes Mellitus/drug therapy/mortality/virology[MESH]
  • |Disseminated Intravascular Coagulation/complications/*drug therapy/mortality/virology[MESH]
  • |Drug Combinations[MESH]
  • |Female[MESH]
  • |Hospital Mortality[MESH]
  • |Humans[MESH]
  • |Hypertension/complications/drug therapy/mortality/virology[MESH]
  • |Iran[MESH]
  • |Lopinavir/therapeutic use[MESH]
  • |Lung/blood supply/drug effects/pathology/virology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Platelet Aggregation Inhibitors/*therapeutic use[MESH]
  • |Pulmonary Embolism/complications/*drug therapy/mortality/virology[MESH]
  • |Respiration, Artificial/mortality/statistics & numerical data[MESH]
  • |Retrospective Studies[MESH]
  • |Ritonavir/therapeutic use[MESH]
  • |SARS-CoV-2/drug effects/*pathogenicity[MESH]
  • |Severity of Illness Index[MESH]
  • |Survival Analysis[MESH]


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