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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Med+Virol 2021 ; 93 (9): 5614-5617 Nephropedia Template TP
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Comparable endemic coronavirus nucleoprotein-specific antibodies in mild and severe Covid-19 patients #MMPMID33913546
Leach S; Harandi AM; Bergstrom T; Andersson LM; Nilsson S; van der Hoek L; Gisslen M
J Med Virol 2021[Sep]; 93 (9): 5614-5617 PMID33913546show ga
The severity of disease of Covid-19 is highly variable, ranging from asymptomatic to critical respiratory disease and death. Potential cross-reactive immune responses between SARS-CoV-2 and endemic coronavirus (eCoV) may hypothetically contribute to this variability. We herein studied if eCoV nucleoprotein (N)-specific antibodies in the sera of patients with mild or severe Covid-19 are associated with Covid-19 severity. There were comparable levels of eCoV N-specific antibodies early and during the first month of infection in Covid-19 patients with mild and severe symptoms, and healthy SARS-CoV-2-negative subjects. These results warrant further studies to investigate the potential role of eCoV-specific antibodies in immunity to SARS-CoV-2 infection.