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Characterization of T lymphocytes in severe COVID-19 patients #MMPMID33913544
Fenoglio D; Dentone C; Parodi A; Di Biagio A; Bozzano F; Vena A; Fabbi M; Ferrera F; Altosole T; Bruzzone B; Giacomini M; Pelosi P; De Maria A; Bassetti M; De Palma R; Filaci G
J Med Virol 2021[Sep]; 93 (9): 5608-5613 PMID33913544show ga
In this observational study, 13 patients with severe COVID-19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID-19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy.