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10.1002/jmv.27040 http://scihub22266oqcxt.onion/10.1002/jmv.27040 33913542!8242519!33913542     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2021 ; 93 (9): 5350-5357 Nephropedia Template TP {{tp|p=33913542|t=2021. Can molecular mimicry explain the cytokine storm of SARS-CoV-2?: An in silico approach |pdf=|usr=}}{{33913542}} gab.com Text Can molecular mimicry explain the cytokine storm of SARS-CoV-2 : An in silico approach JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33913542 #FOAvip PARP14 and PARP9 play a key role in macrophage immune regulation. SARS-CoV-2 is an emerging viral disease that triggers hyper-inflammation known as a cytokine storm. In this study, using in silico tools, we hypothesize about the immunological phenomena of molecular mimicry between SARS-CoV-2 Nsp3 and the human PARP14 and PARP9. The results showed an epitope of SARS-CoV-2 Nsp3 protein that contains consensus sequences for both human PARP14 and PARP9 that are antigens for MHC Classes 1 and 2, which can potentially induce an immune response against human PARP14 and PARP9; while its depletion causes a hyper-inflammatory state in SARS-CoV-2 patients. Twit Text FOAVip Can molecular mimicry explain the cytokine storm of SARS-CoV-2 : An in silico approach ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33913542 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33913542 #FOAvip English Wikipedia <ref>{{Cite pmid|33913542}}</ref> Can molecular mimicry explain the cytokine storm of SARS-CoV-2?: An in silico approach #MMPMID33913542 Obando-Pereda G J Med Virol 2021[Sep]; 93 (9): 5350-5357 PMID33913542show ga PARP14 and PARP9 play a key role in macrophage immune regulation. SARS-CoV-2 is an emerging viral disease that triggers hyper-inflammation known as a cytokine storm. In this study, using in silico tools, we hypothesize about the immunological phenomena of molecular mimicry between SARS-CoV-2 Nsp3 and the human PARP14 and PARP9. The results showed an epitope of SARS-CoV-2 Nsp3 protein that contains consensus sequences for both human PARP14 and PARP9 that are antigens for MHC Classes 1 and 2, which can potentially induce an immune response against human PARP14 and PARP9; while its depletion causes a hyper-inflammatory state in SARS-CoV-2 patients. |Amino Acid Sequence[MESH] |Binding Sites[MESH] |COVID-19/genetics/*immunology/pathology/virology[MESH] |Computer Simulation[MESH] |Consensus Sequence[MESH] |Coronavirus Papain-Like Proteases/*chemistry/genetics/immunology[MESH] |Cytokine Release Syndrome/genetics/*immunology/pathology/virology[MESH] |Epitopes/chemistry/genetics/immunology[MESH] |Gene Expression[MESH] |Histocompatibility Antigens Class I/chemistry/genetics/immunology[MESH] |Histocompatibility Antigens Class II/chemistry/genetics/immunology[MESH] |Host-Pathogen Interactions/genetics/immunology[MESH] |Humans[MESH] |Macrophages/immunology/virology[MESH] |Molecular Docking Simulation[MESH] |Molecular Mimicry[MESH] |Neoplasm Proteins/*chemistry/genetics/immunology[MESH] |Poly(ADP-ribose) Polymerases/*chemistry/genetics/immunology[MESH] |Protein Binding[MESH] |Protein Conformation, alpha-Helical[MESH] |Protein Conformation, beta-Strand[MESH] |Protein Interaction Domains and Motifs[MESH] |SARS-CoV-2/genetics/*immunology/pathogenicity[MESH] |Sequence Alignment[MESH] |Sequence Homology, Amino Acid[MESH]Can molecular mimicry explain the cytokine storm of SARS-CoV-2?: An in(epmc).pdf DeepDyve Pubget Overpricing