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10.1093/cid/ciab330

http://scihub22266oqcxt.onion/10.1093/cid/ciab330
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suck abstract from ncbi


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pmid33912930      Clin+Infect+Dis 2021 ; 73 (Suppl 1): S65-S73
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  • Detection of Severe Acute Respiratory Syndrome Coronavirus 2 on Self-Collected Saliva or Anterior Nasal Specimens Compared With Healthcare Personnel-Collected Nasopharyngeal Specimens #MMPMID33912930
  • Marx GE; Biggerstaff BJ; Nawrocki CC; Totten SE; Travanty EA; Burakoff AW; Scott T; De Hey JC; Carlson JJ; Wendel KA; Harcourt JL; Tamin A; Thomas JD; Rowan SE
  • Clin Infect Dis 2021[Jul]; 73 (Suppl 1): S65-S73 PMID33912930show ga
  • BACKGROUND: Nasopharyngeal specimens (NPS) are commonly used for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing but can be uncomfortable for patients. Self-collected saliva specimens (SS) or anterior nasal specimens (ANS) for SARS-CoV-2 detection are less invasive, but the sensitivity of these specimen types has not been thoroughly evaluated. METHODS: During September-November 2020, 730 adults undergoing SARS-CoV-2 testing at community testing events and homeless shelters in Denver provided self-collected SS and ANS before NPS collection and answered a short survey about symptoms and specimen preference. Specimens were tested for SARS-CoV-2 by means of real-time reverse-transcription polymerase chain reaction (rRT-PCR); viral culture was performed on a subset of specimens positive by rRT-PCR. The sensitivity of SS and ANS for SARS-CoV-2 detection by rRT-PCR was measured against that of NPS. Subgroup analyses included test outcomes by symptom status and culture results. RESULTS: Sensitivity for SARS-CoV-2 detection by rRT-PCR appeared higher for SS than for ANS (85% vs 80%) and higher among symptomatic participants than among those without symptoms (94% vs 29% for SS; 87% vs 50% for ANS). Among participants with culture-positive SARS-CoV-2 by any specimen type, the sensitivities of SS and ANS by rRT-PCR were 94% and 100%, respectively. SS and ANS were equally preferred by participants; most would undergo NPS collection again despite this method's being the least preferred. CONCLUSIONS: SS were slightly more sensitive than ANS for SARS-CoV-2 detection with rRT-PCR. With both SS and ANS, SARS-CoV-2 was reliably detected among participants with symptoms. Self-collected SS and ANS offer practical advantages, are preferred by patients, and might be most useful for testing people with coronavirus disease 2019 symptoms.
  • |*COVID-19[MESH]
  • |*SARS-CoV-2[MESH]
  • |Adult[MESH]
  • |COVID-19 Testing[MESH]
  • |Delivery of Health Care[MESH]
  • |Humans[MESH]
  • |Nasopharynx[MESH]
  • |Saliva[MESH]


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