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10.3389/fimmu.2021.633769 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.633769 33912161!8071932!33912161     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 633769 Nephropedia Template TP {{tp|p=33912161|t=2021. Virus Caused Imbalance of Type I IFN Responses and Inflammation in COVID-19 |pdf=|usr=}}{{33912161}} gab.com Text Virus Caused Imbalance of Type I IFN Responses and Inflammation in COVID-19 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33912161 #FOAvip The global expansion of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as one of the greatest public health challenges and imposes a great threat to human health. Innate immunity plays vital roles in eliminating viruses through initiating type I interferons (IFNs)-dependent antiviral responses and inducing inflammation. Therefore, optimal activation of innate immunity and balanced type I IFN responses and inflammation are beneficial for efficient elimination of invading viruses. However, SARS-CoV-2 manipulates the host's innate immune system by multiple mechanisms, leading to aberrant type I IFN responses and excessive inflammation. In this review, we will emphasize the recent advances in the understanding of the crosstalk between host innate immunity and SARS-CoV-2 to explain the imbalance between inflammation and type I IFN responses caused by viral infection, and explore potential therapeutic targets for COVID-19. Twit Text FOAVip Virus Caused Imbalance of Type I IFN Responses and Inflammation in COVID-19 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33912161 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33912161 #FOAvip English Wikipedia <ref>{{Cite pmid|33912161}}</ref> Virus Caused Imbalance of Type I IFN Responses and Inflammation in COVID-19 #MMPMID33912161 Zhang J; Zhao C; Zhao W Front Immunol 2021[]; 12 (ä): 633769 PMID33912161show ga The global expansion of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as one of the greatest public health challenges and imposes a great threat to human health. Innate immunity plays vital roles in eliminating viruses through initiating type I interferons (IFNs)-dependent antiviral responses and inducing inflammation. Therefore, optimal activation of innate immunity and balanced type I IFN responses and inflammation are beneficial for efficient elimination of invading viruses. However, SARS-CoV-2 manipulates the host's innate immune system by multiple mechanisms, leading to aberrant type I IFN responses and excessive inflammation. In this review, we will emphasize the recent advances in the understanding of the crosstalk between host innate immunity and SARS-CoV-2 to explain the imbalance between inflammation and type I IFN responses caused by viral infection, and explore potential therapeutic targets for COVID-19. |COVID-19 Drug Treatment[MESH] |COVID-19/*immunology[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Inflammation[MESH] |Interferon Type I/*immunology/therapeutic use[MESH] |Lung/immunology[MESH] |SARS-CoV-2/*immunology[MESH] |Signal Transduction[MESH]Virus Caused Imbalance of Type I IFN Responses and Inflammation in COV(epmc).pdf DeepDyve Pubget Overpricing