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10.3389/fphys.2021.578708 http://scihub22266oqcxt.onion/10.3389/fphys.2021.578708 33912067!8072381!33912067     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Physiol 2021 ; 12 (ä): 578708 Nephropedia Template TP {{tp|p=33912067|t=2021. The Affinity of Hemoglobin for Oxygen Is Not Altered During COVID-19 |pdf=|usr=}}{{33912067}} gab.com Text The Affinity of Hemoglobin for Oxygen Is Not Altered During COVID-19 JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=33912067 #FOAvip Background: A computational proteomic analysis suggested that SARS-CoV-2 might bind to hemoglobin (Hb). The authors hypothesized that this phenomenon could result in a decreased oxygen (O(2)) binding and lead to hemolytic anemia as well. The aim of this work was to investigate whether the affinity of Hb for O(2) was altered during COVID-19. Methods: In this retrospective, observational, single-center study, the blood gas analyses of 100 COVID-19 patients were compared to those of 100 non-COVID-19 patients. Fifty-five patients with carboxyhemoglobin (HbCO) >/=8% and 30 with sickle cell disease (SCD) were also included ("positive controls" with abnormal Hb affinity). P(50) was corrected for body temperature, pH, and PCO(2). Results: Patients did not differ statistically for age or sex ratio in COVID-19 and non-COVID-19 groups. Median P(50) at baseline was 26 mmHg [25.2-26.8] vs. 25.9 mmHg [24-27.3], respectively (p = 0.42). As expected, P(50) was 22.5 mmHg [21.6-23.8] in the high HbCO group and 29.3 mmHg [27-31.5] in the SCD group (p < 0.0001). Whatever the disease severity, samples from COVID-19 to non-COVID-19 groups were distributed on the standard O(2)-Hb dissociation curve. When considering the time-course of P(50) between days 1 and 18 in both groups, no significant difference was observed. Median Hb concentration at baseline was 14 g.dl(-1) [12.6-15.2] in the COVID-19 group vs. 13.2 g.dl(-1) [11.4-14.7] in the non-COVID-19 group (p = 0.006). Among the 24 COVID-19 patients displaying anemia, none of them exhibited obvious biological hemolysis. Conclusion: There was no biological argument to support the hypothesis that SARS-CoV-2 could alter O(2) binding to Hb. Twit Text FOAVip The Affinity of Hemoglobin for Oxygen Is Not Altered During COVID-19 ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=33912067 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33912067 #FOAvip English Wikipedia <ref>{{Cite pmid|33912067}}</ref> The Affinity of Hemoglobin for Oxygen Is Not Altered During COVID-19 #MMPMID33912067 Gille T; Sese L; Aubourg E; Fabre EE; Cymbalista F; Ratnam KC; Valeyre D; Nunes H; Richalet JP; Planes C Front Physiol 2021[]; 12 (ä): 578708 PMID33912067show ga Background: A computational proteomic analysis suggested that SARS-CoV-2 might bind to hemoglobin (Hb). The authors hypothesized that this phenomenon could result in a decreased oxygen (O(2)) binding and lead to hemolytic anemia as well. The aim of this work was to investigate whether the affinity of Hb for O(2) was altered during COVID-19. Methods: In this retrospective, observational, single-center study, the blood gas analyses of 100 COVID-19 patients were compared to those of 100 non-COVID-19 patients. Fifty-five patients with carboxyhemoglobin (HbCO) >/=8% and 30 with sickle cell disease (SCD) were also included ("positive controls" with abnormal Hb affinity). P(50) was corrected for body temperature, pH, and PCO(2). Results: Patients did not differ statistically for age or sex ratio in COVID-19 and non-COVID-19 groups. Median P(50) at baseline was 26 mmHg [25.2-26.8] vs. 25.9 mmHg [24-27.3], respectively (p = 0.42). As expected, P(50) was 22.5 mmHg [21.6-23.8] in the high HbCO group and 29.3 mmHg [27-31.5] in the SCD group (p < 0.0001). Whatever the disease severity, samples from COVID-19 to non-COVID-19 groups were distributed on the standard O(2)-Hb dissociation curve. When considering the time-course of P(50) between days 1 and 18 in both groups, no significant difference was observed. Median Hb concentration at baseline was 14 g.dl(-1) [12.6-15.2] in the COVID-19 group vs. 13.2 g.dl(-1) [11.4-14.7] in the non-COVID-19 group (p = 0.006). Among the 24 COVID-19 patients displaying anemia, none of them exhibited obvious biological hemolysis. Conclusion: There was no biological argument to support the hypothesis that SARS-CoV-2 could alter O(2) binding to Hb. äThe Affinity of Hemoglobin for Oxygen Is Not Altered During COVID-19 (epmc).pdf DeepDyve Pubget Overpricing