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10.1016/j.carbpol.2021.118011 http://scihub22266oqcxt.onion/10.1016/j.carbpol.2021.118011 33910715!8025548!33910715     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Carbohydr+Polym 2021 ; 264 (ä): 118011 Nephropedia Template TP {{tp|p=33910715|t=2021. Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: Characterization of electrospun- and lyophilized formulations |pdf=|usr=}}{{33910715}} gab.com Text Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: Characterization of electrospun- and lyophilized formulations JO: Carbohydr Polym http://www.kidney.de/pget.php?&tw=1&pmid=33910715 #FOAvip Veklury by Gilead Sciences, Inc., containing antiviral drug, remdesivir (REM) has received emergency authorization in the USA and in Europe for COVID-19 therapy. Here, for the first time, we describe details of the non-covalent, host-guest type interaction between REM and the solubilizing excipient, sulfobutylether-beta-cyclodextrin (SBECD) that results in significant solubility enhancement. Complete amorphousness of the cyclodextrin-enabled REM formulation was demonstrated by X-ray diffraction, thermal analysis, Raman chemical mapping and electron microscopy/energy dispersive spectroscopy. The use of solubilizing carbohydrate resulted in a 300-fold improvement of the aqueous solubility of REM, and enhanced dissolution rate of the drug enabling the preparation of stable infusion solutions for therapy. 2D ROESY NMR spectroscopy provided information on the nature of REM-excipient interaction and indicated the presence of inclusion phenomenon and the electrostatic attraction between anionic SBECD and nitrogen-containing REM in aqueous solution. Twit Text FOAVip Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: Characterization of electrospun- and lyophilized formulations ????Carbohydr Polym http://www.kidney.de/pget.php?&tw=1&pmid=33910715 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33910715 #FOAvip English Wikipedia <ref>{{Cite pmid|33910715}}</ref> Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: Characterization of electrospun- and lyophilized formulations #MMPMID33910715 Szente L; Puskas I; Sohajda T; Varga E; Vass P; Nagy ZK; Farkas A; Varnai B; Beni S; Hazai E Carbohydr Polym 2021[Jul]; 264 (ä): 118011 PMID33910715show ga Veklury by Gilead Sciences, Inc., containing antiviral drug, remdesivir (REM) has received emergency authorization in the USA and in Europe for COVID-19 therapy. Here, for the first time, we describe details of the non-covalent, host-guest type interaction between REM and the solubilizing excipient, sulfobutylether-beta-cyclodextrin (SBECD) that results in significant solubility enhancement. Complete amorphousness of the cyclodextrin-enabled REM formulation was demonstrated by X-ray diffraction, thermal analysis, Raman chemical mapping and electron microscopy/energy dispersive spectroscopy. The use of solubilizing carbohydrate resulted in a 300-fold improvement of the aqueous solubility of REM, and enhanced dissolution rate of the drug enabling the preparation of stable infusion solutions for therapy. 2D ROESY NMR spectroscopy provided information on the nature of REM-excipient interaction and indicated the presence of inclusion phenomenon and the electrostatic attraction between anionic SBECD and nitrogen-containing REM in aqueous solution. |Adenosine Monophosphate/*analogs & derivatives/chemistry[MESH] |Alanine/*analogs & derivatives/chemistry[MESH] |Antiviral Agents/chemistry[MESH] |COVID-19 Drug Treatment[MESH] |Calorimetry, Differential Scanning[MESH] |Excipients/*chemistry[MESH] |Freeze Drying/methods[MESH] |Magnetic Resonance Spectroscopy[MESH] |Microscopy, Electron, Scanning[MESH] |Molecular Docking Simulation[MESH] |Nanofibers/chemistry[MESH] |Powders[MESH] |Solubility[MESH] |Spectrum Analysis, Raman[MESH] |X-Ray Diffraction[MESH]Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: Charac(epmc).pdf DeepDyve Pubget Overpricing