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10.1016/j.clinimag.2021.04.008

http://scihub22266oqcxt.onion/10.1016/j.clinimag.2021.04.008
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33910141!8058052!33910141
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suck abstract from ncbi


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pmid33910141      Clin+Imaging 2021 ; 79 (ä): 96-101
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  • Automated quantitative thin slice volumetric low dose CT analysis predicts disease severity in COVID-19 patients #MMPMID33910141
  • Stoleriu MG; Gerckens M; Obereisenbuchner F; Zaimova I; Hetrodt J; Mavi SC; Schmidt F; Schoenlebe AA; Heinig-Menhard K; Koch I; Jorres RA; Spiro J; Nowak L; Hatz R; Behr J; Gesierich W; Heiss-Neumann M; Dinkel J
  • Clin Imaging 2021[Nov]; 79 (ä): 96-101 PMID33910141show ga
  • PURPOSE: This study aimed to identify predictive (bio-)markers for COVID-19 severity derived from automated quantitative thin slice low dose volumetric CT analysis, clinical chemistry and lung function testing. METHODS: Seventy-four COVID-19 patients admitted between March 16th and June 3rd 2020 to the Asklepios Lung Clinic Munich-Gauting, Germany, were included in the study. Patients were categorized in a non-severe group including patients hospitalized on general wards only and in a severe group including patients requiring intensive care treatment. Fully automated quantification of CT scans was performed via IMBIO CT Lung Texture analysis software. Predictive biomarkers were assessed with receiver-operator-curve and likelihood analysis. RESULTS: Fifty-five patients (44% female) presented with non-severe COVID-19 and 19 patients (32% female) with severe disease. Five fatalities were reported in the severe group. Accurate automated CT analysis was possible with 61 CTs (82%). Disease severity was linked to lower residual normal lung (72.5% vs 87%, p = 0.003), increased ground glass opacities (GGO) (8% vs 5%, p = 0.031) and increased reticular pattern (8% vs 2%, p = 0.025). Disease severity was associated with advanced age (76 vs 59 years, p = 0.001) and elevated serum C-reactive protein (CRP, 92.2 vs 36.3 mg/L, p < 0.001), lactate dehydrogenase (LDH, 485 vs 268 IU/L, p < 0.001) and oxygen supplementation (p < 0.001) upon admission. Predictive risk factors for the development of severe COVID-19 were oxygen supplementation, LDH >313 IU/L, CRP >71 mg/L, <70% normal lung texture, >12.5% GGO and >4.5% reticular pattern. CONCLUSION: Automated low dose CT analysis upon admission might be a useful tool to predict COVID-19 severity in patients.
  • |*COVID-19[MESH]
  • |Cone-Beam Computed Tomography[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lung/diagnostic imaging[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]


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