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10.15252/embr.202152744 http://scihub22266oqcxt.onion/10.15252/embr.202152744 33908688!8183417!33908688     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2021 ; 22 (6): e52744 Nephropedia Template TP {{tp|p=33908688|t=2021. Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-on-chip model |pdf=|usr=}}{{33908688}} gab.com Text Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-on-chip model JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=33908688 #FOAvip Severe cases of SARS-CoV-2 infection are characterized by hypercoagulopathies and systemic endotheliitis of the lung microvasculature. The dynamics of vascular damage, and whether it is a direct consequence of endothelial infection or an indirect consequence of an immune cell-mediated cytokine storm remain unknown. Using a vascularized lung-on-chip model, we find that infection of alveolar epithelial cells leads to limited apical release of virions, consistent with reports of monoculture infection. However, viral RNA and proteins are rapidly detected in underlying endothelial cells, which are themselves refractory to apical infection in monocultures. Although endothelial infection is unproductive, it leads to the formation of cell clusters with low CD31 expression, a progressive loss of barrier integrity and a pro-coagulatory microenvironment. Viral RNA persists in individual cells generating an inflammatory response, which is transient in epithelial cells but persistent in endothelial cells and typified by IL-6 secretion even in the absence of immune cells. Inhibition of IL-6 signalling with tocilizumab reduces but does not prevent loss of barrier integrity. SARS-CoV-2-mediated endothelial cell damage thus occurs independently of cytokine storm. Twit Text FOAVip Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-on-chip model ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=33908688 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33908688 #FOAvip English Wikipedia <ref>{{Cite pmid|33908688}}</ref> Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-on-chip model #MMPMID33908688 Thacker VV; Sharma K; Dhar N; Mancini GF; Sordet-Dessimoz J; McKinney JD EMBO Rep 2021[Jun]; 22 (6): e52744 PMID33908688show ga Severe cases of SARS-CoV-2 infection are characterized by hypercoagulopathies and systemic endotheliitis of the lung microvasculature. The dynamics of vascular damage, and whether it is a direct consequence of endothelial infection or an indirect consequence of an immune cell-mediated cytokine storm remain unknown. Using a vascularized lung-on-chip model, we find that infection of alveolar epithelial cells leads to limited apical release of virions, consistent with reports of monoculture infection. However, viral RNA and proteins are rapidly detected in underlying endothelial cells, which are themselves refractory to apical infection in monocultures. Although endothelial infection is unproductive, it leads to the formation of cell clusters with low CD31 expression, a progressive loss of barrier integrity and a pro-coagulatory microenvironment. Viral RNA persists in individual cells generating an inflammatory response, which is transient in epithelial cells but persistent in endothelial cells and typified by IL-6 secretion even in the absence of immune cells. Inhibition of IL-6 signalling with tocilizumab reduces but does not prevent loss of barrier integrity. SARS-CoV-2-mediated endothelial cell damage thus occurs independently of cytokine storm. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Cytokine Release Syndrome[MESH] |Endothelial Cells[MESH] |Humans[MESH]Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infect(epmc).pdf DeepDyve Pubget Overpricing