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10.1515/cclm-2021-0455

http://scihub22266oqcxt.onion/10.1515/cclm-2021-0455
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33908222!ä!33908222

suck abstract from ncbi


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pmid33908222      Clin+Chem+Lab+Med 2021 ; 59 (9): 1507-1515
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  • IFCC interim guidelines on rapid point-of-care antigen testing for SARS-CoV-2 detection in asymptomatic and symptomatic individuals #MMPMID33908222
  • Bohn MK; Lippi G; Horvath AR; Erasmus R; Grimmler M; Gramegna M; Mancini N; Mueller R; Rawlinson WD; Menezes ME; Patru MM; Rota F; Sethi S; Singh K; Yuen KY; Wang CB; Adeli K
  • Clin Chem Lab Med 2021[Aug]; 59 (9): 1507-1515 PMID33908222show ga
  • With an almost unremittent progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections all around the world, there is a compelling need to introduce rapid, reliable, and high-throughput testing to allow appropriate clinical management and/or timely isolation of infected individuals. Although nucleic acid amplification testing (NAAT) remains the gold standard for detecting and theoretically quantifying SARS-CoV-2 mRNA in various specimen types, antigen assays may be considered a suitable alternative, under specific circumstances. Rapid antigen tests are meant to detect viral antigen proteins in biological specimens (e.g. nasal, nasopharyngeal, saliva), to indicate current SARS-CoV-2 infection. The available assay methodology includes rapid chromatographic immunoassays, used at the point-of-care, which carries some advantages and drawbacks compared to more conventional, instrumentation-based, laboratory immunoassays. Therefore, this document by the International Federation for Clinical Chemistry and Laboratory Medicine (IFCC) Taskforce on COVID-19 aims to summarize available data on the performance of currently available SARS-CoV-2 antigen rapid detection tests (Ag-RDTs), providing interim guidance on clinical indications and target populations, assay selection, and evaluation, test interpretation and limitations, as well as on pre-analytical considerations. This document is hence mainly aimed to assist laboratory and regulated health professionals in selecting, validating, and implementing regulatory approved Ag-RDTs.
  • |Antigens, Viral/*immunology[MESH]
  • |Asymptomatic Infections/classification[MESH]
  • |COVID-19/*diagnosis/immunology/virology[MESH]
  • |Humans[MESH]
  • |Immunoassay/*standards[MESH]
  • |Point-of-Care Testing/*standards[MESH]
  • |Practice Guidelines as Topic/*standards[MESH]


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