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10.1016/j.matt.2021.04.005 http://scihub22266oqcxt.onion/10.1016/j.matt.2021.04.005 33907732!8062026!33907732     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Matter 2021 ; 4 (6): 2059-2082 Nephropedia Template TP {{tp|p=33907732|t=2021. Nanotraps for the containment and clearance of SARS-CoV-2 |pdf=|usr=}}{{33907732}} gab.com Text Nanotraps for the containment and clearance of SARS-CoV-2 JO: Matter http://www.kidney.de/pget.php?&tw=1&pmid=33907732 #FOAvip SARS-CoV-2 enters host cells through its viral spike protein binding to angiotensin-converting enzyme 2 (ACE2) receptors on the host cells. Here, we show that functionalized nanoparticles, termed "Nanotraps," completely inhibited SARS-CoV-2 infection by blocking the interaction between the spike protein of SARS-CoV-2 and the ACE2 of host cells. The liposomal-based Nanotrap surfaces were functionalized with either recombinant ACE2 proteins or anti-SARS-CoV-2 neutralizing antibodies and phagocytosis-specific phosphatidylserines. The Nanotraps effectively captured SARS-CoV-2 and completely blocked SARS-CoV-2 infection to ACE2-expressing human cell lines and primary lung cells; the phosphatidylserine triggered subsequent phagocytosis of the virus-bound, biodegradable Nanotraps by macrophages, leading to the clearance of pseudotyped and authentic virus in vitro. Furthermore, the Nanotraps demonstrated an excellent biosafety profile in vitro and in vivo. Finally, the Nanotraps inhibited pseudotyped SARS-CoV-2 infection in live human lungs in an ex vivo lung perfusion system. In summary, Nanotraps represent a new nanomedicine for the inhibition of SARS-CoV-2 infection. Twit Text FOAVip Nanotraps for the containment and clearance of SARS-CoV-2 ????Matter http://www.kidney.de/pget.php?&tw=1&pmid=33907732 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33907732 #FOAvip English Wikipedia <ref>{{Cite pmid|33907732}}</ref> Nanotraps for the containment and clearance of SARS-CoV-2 #MMPMID33907732 Chen M; Rosenberg J; Cai X; Lee ACH; Shi J; Nguyen M; Wignakumar T; Mirle V; Edobor AJ; Fung J; Donington JS; Shanmugarajah K; Lin Y; Chang E; Randall G; Penaloza-MacMaster P; Tian B; Madariaga ML; Huang J Matter 2021[Jun]; 4 (6): 2059-2082 PMID33907732show ga SARS-CoV-2 enters host cells through its viral spike protein binding to angiotensin-converting enzyme 2 (ACE2) receptors on the host cells. Here, we show that functionalized nanoparticles, termed "Nanotraps," completely inhibited SARS-CoV-2 infection by blocking the interaction between the spike protein of SARS-CoV-2 and the ACE2 of host cells. The liposomal-based Nanotrap surfaces were functionalized with either recombinant ACE2 proteins or anti-SARS-CoV-2 neutralizing antibodies and phagocytosis-specific phosphatidylserines. The Nanotraps effectively captured SARS-CoV-2 and completely blocked SARS-CoV-2 infection to ACE2-expressing human cell lines and primary lung cells; the phosphatidylserine triggered subsequent phagocytosis of the virus-bound, biodegradable Nanotraps by macrophages, leading to the clearance of pseudotyped and authentic virus in vitro. Furthermore, the Nanotraps demonstrated an excellent biosafety profile in vitro and in vivo. Finally, the Nanotraps inhibited pseudotyped SARS-CoV-2 infection in live human lungs in an ex vivo lung perfusion system. In summary, Nanotraps represent a new nanomedicine for the inhibition of SARS-CoV-2 infection. äNanotraps for the containment and clearance of SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing