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10.1080/14737159.2021.1919513

http://scihub22266oqcxt.onion/10.1080/14737159.2021.1919513
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suck abstract from ncbi


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pmid33906571      Expert+Rev+Mol+Diagn 2021 ; 21 (5): 515-518
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  • Performance comparison of the Cobas(R) Liat(R) and Cepheid(R) GeneXpert(R) systems on SARS-CoV-2 detection in nasopharyngeal swab and posterior oropharyngeal saliva #MMPMID33906571
  • Tsang HF; Leung WMS; Chan LWC; Cho WCS; Wong SCC
  • Expert Rev Mol Diagn 2021[May]; 21 (5): 515-518 PMID33906571show ga
  • Background: Nucleic acid amplification tests (NAATs) based methods such as real-time reverse transcription polymerase-chain reaction (real-time RT-PCR) are the gold standard for diagnosis of current infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The cobas(R) Liat(R) and cepheid(R) GeneXpert(R) systems are two rapid real-time RT-PCR platforms offering rapid, specimen-to-answer detection of SARS-CoV-2.Research design and methods: In this study, we compared the performance of these two systems on SARS-CoV-2 detection in 9 nasopharyngeal swab (NPS) and 70 posterior oropharyngeal saliva specimens collected from 79 patients suspected of SARS-CoV-2 infection between August 2020 and March 2021.Results: The Positive Percent Agreement (PPA), Negative Percent Agreement (NPA) and overall Percent Agreement (OPA) between cepheid(R) Xpress SARS-CoV-2 assay and cobas(R) Liat(R) SARS-CoV-2 & Influenza A/B assay were found to be 100%. We demonstrated an excellent overall test concordance of the Liat(R) SARS-CoV-2 & Influenza A/B assay and Xpress SARS-CoV-2 assay. The small sample size of SARS-CoV-2 positive and weak-positive specimens is the inherent limitation of this study.Conclusions: The performance of the cobas(R) Liat(R) SARS-CoV-2 & Influenza A/B assay is equivalent to the cepheid(R) Xpress SARS-CoV-2 assay for SARS-CoV-2 detection using NPS and posterior oropharyngeal saliva.
  • |COVID-19 Nucleic Acid Testing/*methods[MESH]
  • |Humans[MESH]
  • |Nasopharynx/*virology[MESH]
  • |Oropharynx/virology[MESH]
  • |Real-Time Polymerase Chain Reaction[MESH]
  • |Saliva/*virology[MESH]


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