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10.1016/j.cellimm.2021.104363

http://scihub22266oqcxt.onion/10.1016/j.cellimm.2021.104363
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suck abstract from ncbi


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pmid33905951      Cell+Immunol 2021 ; 365 (ä): 104363
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  • Functional responsiveness of memory T cells from COVID-19 patients #MMPMID33905951
  • Tavukcuoglu E; Horzum U; Cagkan Inkaya A; Unal S; Esendagli G
  • Cell Immunol 2021[Jul]; 365 (ä): 104363 PMID33905951show ga
  • The presence of memory T cells in COVID-19 patients has been acknowledged, however the functional potency of memory responses is critical for protection. In this study, naive, effector, effector memory, and central memory CD4(+) and CD8(+) T cells obtained from the COVID-19 survivors were re-exposed to autologous monocyte-derived DCs that were loaded with SARS-CoV-2 spike glycoprotein S1. Proliferation capacity, CD25, 4-1BB, and PD-1 expression, and IFN-gamma, IL-6, granzyme, granulysin, and FasL secretion were enhanced in CD4(+) and CD8(+) effector memory and central memory T cells. Albeit being at heterogeneous levels, the memory T cells from the individuals with COVID-19 history possess functional capacities to reinvigorate anti-viral immunity against SARS-CoV-2.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral/immunology[MESH]
  • |Antigens, Viral/immunology[MESH]
  • |CD4-Positive T-Lymphocytes/immunology[MESH]
  • |CD8-Positive T-Lymphocytes/immunology[MESH]
  • |COVID-19/*immunology/metabolism/transmission/virology[MESH]
  • |Dendritic Cells/immunology[MESH]
  • |Epitopes, T-Lymphocyte/immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunologic Memory/*immunology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2/immunology/isolation & purification[MESH]
  • |Spike Glycoprotein, Coronavirus/immunology[MESH]


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