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10.14814/phy2.14843

http://scihub22266oqcxt.onion/10.14814/phy2.14843
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33904656!8077126!33904656
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suck abstract from ncbi


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pmid33904656      Physiol+Rep 2021 ; 9 (7): e14843
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  • Reduced adiponectin levels in patients with COVID-19 acute respiratory failure: A case-control study #MMPMID33904656
  • Kearns SM; Ahern KW; Patrie JT; Horton WB; Harris TE; Kadl A
  • Physiol Rep 2021[Apr]; 9 (7): e14843 PMID33904656show ga
  • Hypoadiponectinemia is speculated to play a key role in the relationship between obesity and COVID-19 respiratory failure. However, only one study has examined adiponectin levels in COVID-19 patients, and none have investigated adiponectin levels strictly in patients with acute respiratory failure. In this study, we performed a retrospective case-control study of adipokine levels in patients with acute respiratory failure caused by either COVID-19 or other viral/bacterial source. All patients with COVID-19 respiratory failure in the University of Virginia Biorepository and Tissue Research database were included. We also selected patients with non-COVID-19 infectious respiratory failure from the same biorepository to serve as a comparison cohort. Plasma adipokine levels were measured on three occasions during the first 72 hours of hospitalization. Twelve patients with COVID-19 respiratory failure and 17 patients with other infectious respiratory failure were studied. Adiponectin levels were significantly lower in patients with COVID-19 respiratory failure, even after adjustment for age, sex, BMI, and other covariates. In conclusion, adiponectin levels appear to be reduced in COVID-19 respiratory failure. Larger studies are needed to confirm this report.
  • |Adiponectin/*blood[MESH]
  • |Aged[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19/*blood/diagnosis[MESH]
  • |Databases, Factual[MESH]
  • |Down-Regulation[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]


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