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10.15252/msb.202110232 http://scihub22266oqcxt.onion/10.15252/msb.202110232 33904651!8077299!33904651     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Syst+Biol 2021 ; 17 (4): e10232 Nephropedia Template TP {{tp|p=33904651|t=2021. Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut |pdf=|usr=}}{{33904651}} gab.com Text Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut JO: Mol Syst Biol http://www.kidney.de/pget.php?&tw=1&pmid=33904651 #FOAvip Exacerbated pro-inflammatory immune response contributes to COVID-19 pathology. However, despite the mounting evidence about SARS-CoV-2 infecting the human gut, little is known about the antiviral programs triggered in this organ. To address this gap, we performed single-cell transcriptomics of SARS-CoV-2-infected intestinal organoids. We identified a subpopulation of enterocytes as the prime target of SARS-CoV-2 and, interestingly, found the lack of positive correlation between susceptibility to infection and the expression of ACE2. Infected cells activated strong pro-inflammatory programs and produced interferon, while expression of interferon-stimulated genes was limited to bystander cells due to SARS-CoV-2 suppressing the autocrine action of interferon. These findings reveal that SARS-CoV-2 curtails the immune response and highlights the gut as a pro-inflammatory reservoir that should be considered to fully understand SARS-CoV-2 pathogenesis. Twit Text FOAVip Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut ????Mol Syst Biol http://www.kidney.de/pget.php?&tw=1&pmid=33904651 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33904651 #FOAvip English Wikipedia <ref>{{Cite pmid|33904651}}</ref> Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut #MMPMID33904651 Triana S; Metz-Zumaran C; Ramirez C; Kee C; Doldan P; Shahraz M; Schraivogel D; Gschwind AR; Sharma AK; Steinmetz LM; Herrmann C; Alexandrov T; Boulant S; Stanifer ML Mol Syst Biol 2021[Apr]; 17 (4): e10232 PMID33904651show ga Exacerbated pro-inflammatory immune response contributes to COVID-19 pathology. However, despite the mounting evidence about SARS-CoV-2 infecting the human gut, little is known about the antiviral programs triggered in this organ. To address this gap, we performed single-cell transcriptomics of SARS-CoV-2-infected intestinal organoids. We identified a subpopulation of enterocytes as the prime target of SARS-CoV-2 and, interestingly, found the lack of positive correlation between susceptibility to infection and the expression of ACE2. Infected cells activated strong pro-inflammatory programs and produced interferon, while expression of interferon-stimulated genes was limited to bystander cells due to SARS-CoV-2 suppressing the autocrine action of interferon. These findings reveal that SARS-CoV-2 curtails the immune response and highlights the gut as a pro-inflammatory reservoir that should be considered to fully understand SARS-CoV-2 pathogenesis. |*Single-Cell Analysis[MESH] |COVID-19/virology[MESH] |Gastrointestinal Microbiome[MESH] |Humans[MESH] |In Situ Hybridization, Fluorescence[MESH] |Intestines/*immunology[MESH] |Organoids/metabolism[MESH] |SARS-CoV-2/*physiology[MESH]Single-cell analyses reveal SARS-CoV-2 interference with intrinsic imm(epmc).pdf DeepDyve Pubget Overpricing