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10.37201/req/042.2021 http://scihub22266oqcxt.onion/10.37201/req/042.2021 33902254!8638831!33902254     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Rev+Esp+Quimioter 2021 ; 34 (5): 402-407 Nephropedia Template TP {{tp|p=33902254|t=2021. Plitidepsina, un inhibidor del factor de elongacion celular eEF1a y molnupiravir un analogo del ribonucleosido citidina, dos nuevos compuestos quimicos con intensa actividad frente al SARS-CoV-2 |pdf=|usr=}}{{33902254}} gab.com Text Plitidepsina, un inhibidor del factor de elongacion celular eEF1a y molnupiravir un analogo del ribonucleosido citidina, dos nuevos compuestos quimicos con intensa actividad frente al SARS-CoV-2 JO: Rev Esp Quimioter http://www.kidney.de/pget.php?&tw=1&pmid=33902254 #FOAvip The knowledge of the replicative cycle of SARS-CoV-2 and its interactions with cellular proteins has opened a new therapeutic possibility based on blocking those essential for the virus. The cellular protein elongation factor eEF1A could be a good target. Among its natural inhibitors are didemnins and their related chemical compounds such as plitidepsin. In human cell culture, this compound is capable of inhibiting the virus with a potency 27,5 times that of remdesivir. It must be administered intravenously. Of the ribonucleoside analogues, molnupiravir (MK-4483/EIDD-2801) (hydroxy-cytidine) determines a lethal mutagenesis on SARS-CoV-2. In animals, after oral administration, the pulmonary viral load decreases 25,000 times and when administered as prophylaxis, approximately 100,000 times. It prevents the transmission of the virus and eliminates its presence in the oropharynx. Both chemicals have started Phase I / II human clinical trials. Twit Text FOAVip Plitidepsina, un inhibidor del factor de elongacion celular eEF1a y molnupiravir un analogo del ribonucleosido citidina, dos nuevos compuestos quimicos con intensa actividad frente al SARS-CoV-2 ????Rev Esp Quimioter http://www.kidney.de/pget.php?&tw=1&pmid=33902254 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33902254 #FOAvip English Wikipedia <ref>{{Cite pmid|33902254}}</ref> Plitidepsina, un inhibidor del factor de elongacion celular eEF1a y molnupiravir un analogo del ribonucleosido citidina, dos nuevos compuestos quimicos con intensa actividad frente al SARS-CoV-2 #MMPMID33902254 Reina J Rev Esp Quimioter 2021[Oct]; 34 (5): 402-407 PMID33902254show ga The knowledge of the replicative cycle of SARS-CoV-2 and its interactions with cellular proteins has opened a new therapeutic possibility based on blocking those essential for the virus. The cellular protein elongation factor eEF1A could be a good target. Among its natural inhibitors are didemnins and their related chemical compounds such as plitidepsin. In human cell culture, this compound is capable of inhibiting the virus with a potency 27,5 times that of remdesivir. It must be administered intravenously. Of the ribonucleoside analogues, molnupiravir (MK-4483/EIDD-2801) (hydroxy-cytidine) determines a lethal mutagenesis on SARS-CoV-2. In animals, after oral administration, the pulmonary viral load decreases 25,000 times and when administered as prophylaxis, approximately 100,000 times. It prevents the transmission of the virus and eliminates its presence in the oropharynx. Both chemicals have started Phase I / II human clinical trials. |*COVID-19[MESH] |*Ribonucleosides[MESH] |Animals[MESH] |Antiviral Agents/pharmacology/therapeutic use[MESH] |Cytidine/analogs & derivatives[MESH] |Depsipeptides[MESH] |Humans[MESH] |Hydroxylamines[MESH] |Peptide Elongation Factors[MESH] |Peptides, Cyclic[MESH]Plitidepsina, un inhibidor del factor de elongacion celular eEF1a y mo(epmc).pdf DeepDyve Pubget Overpricing