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10.1016/j.ijid.2021.04.065

http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.04.065
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suck abstract from ncbi


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pmid33901656      Int+J+Infect+Dis 2021 ; 108 (ä): 231-236
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  • Use of the FebriDx point-of-care test for the exclusion of SARS-CoV-2 diagnosis in a population with acute respiratory infection during the second (COVID-19) wave in Italy #MMPMID33901656
  • Lagi F; Trevisan S; Piccica M; Graziani L; Basile G; Mencarini J; Borchi B; Menicacci L; Vaudo M; Scotti V; Fabbri A; Bandini G; Tozzetti C; Berni A; Aiezza N; Pestelli G; Turchi V; Pignone AM; Poggesi L; Nozzoli C; Morettini A; Rossolini GM; Bartoloni A
  • Int J Infect Dis 2021[Jul]; 108 (ä): 231-236 PMID33901656show ga
  • OBJECTIVE: Evaluate the real-world accuracy of Myxovirus resistance protein A (MxA) detected by the rapid, point-of-care FebriDx test during the second-wave pandemic in Italy in patients with acute respiratory infection (ARI) and a clinical suspicion of COVID-19. DESIGN AND METHODS: Prospective, observational, diagnostic accuracy study whereby hospitalized patients with ARI were consecutively enrolled in a single tertiary care center in Italy from August 1, 2020 to January 31, 2021. RESULTS: COVID-19 was diagnosed in 136/200 (68.0%) patients and Non-COVID-19 was diagnosed in 64/200 (32.0%) patients. COVID-19 patients were younger and had a lower Charlson comorbidity index compared to Non-COVID-19 patients (p < 0.001). Concordance between FebriDx, MxA and rt-PCR for SARS-CoV-2 (gold standard) was good (k 0.93, 95% CI 0.87-0.99). Overall sensitivity and specificity were 97.8% [95% CI 93.7-99.5] and 95.3% [95% CI 86.9%-99.0%], respectively. FebriDx demonstrated a negative predictive value of 95.3% (95% CI 86.9-99.0) for an observed disease prevalence of 68%. CONCLUSIONS: FebriDx MxA showed high diagnostic accuracy to identify COVID-19 and could be considered as a real-time triage tool to streamline the management of suspected COVID-19 patients. FebriDx also detected bacterial etiology in Non-COVID-19 patients suggesting good performance to distinguish bacterial from viral respiratory infection.
  • |*COVID-19[MESH]
  • |*SARS-CoV-2[MESH]
  • |COVID-19 Testing[MESH]
  • |Humans[MESH]
  • |Italy/epidemiology[MESH]
  • |Point-of-Care Testing[MESH]
  • |Prospective Studies[MESH]


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