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10.12659/MSM.932899

http://scihub22266oqcxt.onion/10.12659/MSM.932899
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33900279!8086413!33900279
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suck abstract from ncbi


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pmid33900279      Med+Sci+Monit 2021 ; 27 (ä): e932899
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  • Editorial: SARS-CoV-2 mRNA Vaccines and the Possible Mechanism of Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) #MMPMID33900279
  • Parums DV
  • Med Sci Monit 2021[Apr]; 27 (ä): e932899 PMID33900279show ga
  • During 2020 and 2021, the global pandemic of coronavirus disease 2019 (COVID-19) due to severe acute respi- ratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in high death rates and acute and chronic morbidity in all countries. The rapid development of new mRNA vaccines to SARS-CoV-2 brings hope that the spread of this virus can be controlled. The ChAdOx1 nCoV-19 vaccine developed by a collaboration between the University of Oxford and AstraZeneca showed efficacy in clinical trials, with a good safety profile. However, there have been recent reports of the rare development of thrombotic events in young women following vaccination with ChAdOx1 nCoV-19, particularly of the rare condition of cavernous sinus thrombosis. Studies have begun to in- vestigate whether antibodies to the SARS-CoV-2 spike cross-react with platelet factor 4 (PF4/CXLC4) and mim- ic autoimmune heparin-induced thrombocytopenia. This Medical Science Monitor Editorial aims to briefly update the current status of studies on a possible rare complication of using new mRNA vaccines to prevent COVID-19.
  • |*RNA, Messenger/genetics/immunology[MESH]
  • |*SARS-CoV-2/genetics/immunology[MESH]
  • |COVID-19 Vaccines/*adverse effects/genetics/immunology[MESH]
  • |COVID-19/*complications/prevention & control[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Humans[MESH]


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