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Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Emerg+Infect+Dis 2021 ; 27 (5): 1492-1495 Nephropedia Template TP
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Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China #MMPMID33900193
Chu DKW; Hui KPY; Gu H; Ko RLW; Krishnan P; Ng DYM; Liu GYZ; Wan CKC; Cheung MC; Ng KC; Nicholls JM; Tsang DNC; Peiris M; Chan MCW; Poon LLM
Emerg Infect Dis 2021[May]; 27 (5): 1492-1495 PMID33900193show ga
We describe an introduction of clade GH severe acute respiratory syndrome coronavirus 2 causing a fourth wave of coronavirus disease in Hong Kong. The virus has an ORF3a-Q57H mutation, causing truncation of ORF3b. This virus evades induction of cytokine, chemokine, and interferon-stimulated gene expression in primary human respiratory cells.