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10.7554/eLife.65534 http://scihub22266oqcxt.onion/10.7554/eLife.65534 33899740!8195606!33899740     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2021 ; 10 (ä): ä Nephropedia Template TP {{tp|p=33899740|t=2021. High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing |pdf=|usr=}}{{33899740}} gab.com Text High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=33899740 #FOAvip BACKGROUND: Understanding changes in infectiousness during SARS-COV-2 infections is critical to assess the effectiveness of public health measures such as contact tracing. METHODS: Here, we develop a novel mechanistic approach to infer the infectiousness profile of SARS-COV-2-infected individuals using data from known infector-infectee pairs. We compare estimates of key epidemiological quantities generated using our mechanistic method with analogous estimates generated using previous approaches. RESULTS: The mechanistic method provides an improved fit to data from SARS-CoV-2 infector-infectee pairs compared to commonly used approaches. Our best-fitting model indicates a high proportion of presymptomatic transmissions, with many transmissions occurring shortly before the infector develops symptoms. CONCLUSIONS: High infectiousness immediately prior to symptom onset highlights the importance of continued contact tracing until effective vaccines have been distributed widely, even if contacts from a short time window before symptom onset alone are traced. FUNDING: Engineering and Physical Sciences Research Council (EPSRC). Twit Text FOAVip High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=33899740 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33899740 #FOAvip English Wikipedia <ref>{{Cite pmid|33899740}}</ref> High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing #MMPMID33899740 Hart WS; Maini PK; Thompson RN Elife 2021[Apr]; 10 (ä): ä PMID33899740show ga BACKGROUND: Understanding changes in infectiousness during SARS-COV-2 infections is critical to assess the effectiveness of public health measures such as contact tracing. METHODS: Here, we develop a novel mechanistic approach to infer the infectiousness profile of SARS-COV-2-infected individuals using data from known infector-infectee pairs. We compare estimates of key epidemiological quantities generated using our mechanistic method with analogous estimates generated using previous approaches. RESULTS: The mechanistic method provides an improved fit to data from SARS-CoV-2 infector-infectee pairs compared to commonly used approaches. Our best-fitting model indicates a high proportion of presymptomatic transmissions, with many transmissions occurring shortly before the infector develops symptoms. CONCLUSIONS: High infectiousness immediately prior to symptom onset highlights the importance of continued contact tracing until effective vaccines have been distributed widely, even if contacts from a short time window before symptom onset alone are traced. FUNDING: Engineering and Physical Sciences Research Council (EPSRC). |COVID-19/epidemiology/*transmission[MESH] |Carrier State/epidemiology/transmission[MESH] |Contact Tracing/*methods[MESH] |Health Policy[MESH] |Humans[MESH] |Models, Theoretical[MESH] |Public Health[MESH] |Risk Factors[MESH]High infectiousness immediately before COVID-19 symptom onset highligh(epmc).pdf DeepDyve Pubget Overpricing