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10.1177/15353702211008106 http://scihub22266oqcxt.onion/10.1177/15353702211008106 33899542!8090827!33899542     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Biol+Med+(Maywood) 2021 ; 246 (14): 1643-1649 Nephropedia Template TP {{tp|p=33899542|t=2021. Manipulation of genes could inhibit SARS-CoV-2 infection that causes COVID-19 pandemics |pdf=|usr=}}{{33899542}} gab.com Text Manipulation of genes could inhibit SARS-CoV-2 infection that causes COVID-19 pandemics JO: Exp Biol Med (Maywood) http://www.kidney.de/pget.php?&tw=1&pmid=33899542 #FOAvip The year 2020 witnessed an unpredictable pandemic situation due to novel coronavirus (COVID-19) outbreaks. This condition can be more severe if the patient has comorbidities. Failure of viable treatment for such viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is due to lack of identification. Thus, modern and productive biotechnology-based tools are being used to manipulate target genes by introducing the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas (CRISPR-associated) system. Moreover, it has now been used as a tool to inhibit viral replication. Hence, it can be hypothesized that the CRISPR/Cas system can be a viable tool to target both the SARS-CoV-2 genome with specific target RNA sequence and host factors to destroy the SARS-CoV-2 community via inhibition of viral replication and infection. Moreover, comorbidities and COVID-19 escalate the rate of mortality globally, and as a result, we have faced this pandemic. CRISPR/Cas-mediated genetic manipulation to knockdown viral sequences may be a preventive strategy against such pandemic caused by SARS-CoV-2. Furthermore, prophylactic antiviral CRISPR in human cells (PAC-MAN) along with CRISPR/Cas13d efficiently degrades the specific RNA sequence to inhibit viral replication. Therefore, we suggest that CRISPR/Cas system with PAC-MAN could be a useful tool to fight against such a global pandemic caused by SARS-CoV-2. This is an alternative preventive approach of management against the pandemic to destroy the target sequence of RNA in SARS-CoV-2 by viral inhibition. Twit Text FOAVip Manipulation of genes could inhibit SARS-CoV-2 infection that causes COVID-19 pandemics ????Exp Biol Med (Maywood) http://www.kidney.de/pget.php?&tw=1&pmid=33899542 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33899542 #FOAvip English Wikipedia <ref>{{Cite pmid|33899542}}</ref> Manipulation of genes could inhibit SARS-CoV-2 infection that causes COVID-19 pandemics #MMPMID33899542 Banerjee A; Mukherjee S; Maji BK Exp Biol Med (Maywood) 2021[Jul]; 246 (14): 1643-1649 PMID33899542show ga The year 2020 witnessed an unpredictable pandemic situation due to novel coronavirus (COVID-19) outbreaks. This condition can be more severe if the patient has comorbidities. Failure of viable treatment for such viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is due to lack of identification. Thus, modern and productive biotechnology-based tools are being used to manipulate target genes by introducing the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas (CRISPR-associated) system. Moreover, it has now been used as a tool to inhibit viral replication. Hence, it can be hypothesized that the CRISPR/Cas system can be a viable tool to target both the SARS-CoV-2 genome with specific target RNA sequence and host factors to destroy the SARS-CoV-2 community via inhibition of viral replication and infection. Moreover, comorbidities and COVID-19 escalate the rate of mortality globally, and as a result, we have faced this pandemic. CRISPR/Cas-mediated genetic manipulation to knockdown viral sequences may be a preventive strategy against such pandemic caused by SARS-CoV-2. Furthermore, prophylactic antiviral CRISPR in human cells (PAC-MAN) along with CRISPR/Cas13d efficiently degrades the specific RNA sequence to inhibit viral replication. Therefore, we suggest that CRISPR/Cas system with PAC-MAN could be a useful tool to fight against such a global pandemic caused by SARS-CoV-2. This is an alternative preventive approach of management against the pandemic to destroy the target sequence of RNA in SARS-CoV-2 by viral inhibition. |*Gene Transfer Techniques[MESH] |Antiviral Agents/administration & dosage/*pharmacology[MESH] |COVID-19/epidemiology/genetics/*virology[MESH] |CRISPR-Cas Systems[MESH] |Gene Editing/methods[MESH] |Host-Pathogen Interactions/genetics/*physiology[MESH] |Humans[MESH] |RNA, Guide, CRISPR-Cas Systems/administration & dosage/pharmacology[MESH]Manipulation of genes could inhibit SARS-CoV-2 infection that causes C(epmc).pdf DeepDyve Pubget Overpricing