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10.1016/j.xcrm.2021.100275 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2021.100275 33899033!8057765!33899033     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2021 ; 2 (5): 100275 Nephropedia Template TP {{tp|p=33899033|t=2021. Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies |pdf=|usr=}}{{33899033}} gab.com Text Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33899033 #FOAvip Many SARS-CoV-2-infected individuals remain asymptomatic. Little is known about the extent and quality of their antiviral humoral response. Here, we analyze antibody functions in 52 asymptomatic infected individuals, 119 mildly symptomatic, and 21 hospitalized patients with COVID-19. We measure anti-spike immunoglobulin G (IgG), IgA, and IgM levels with the S-Flow assay and map IgG-targeted epitopes with a Luminex assay. We also evaluate neutralization, complement deposition, and antibody-dependent cellular cytotoxicity (ADCC) using replication-competent SARS-CoV-2 or reporter cell systems. We show that COVID-19 sera mediate complement deposition and kill infected cells by ADCC. Sera from asymptomatic individuals neutralize the virus, activate ADCC, and trigger complement deposition. Antibody levels and functions are lower in asymptomatic individuals than they are in symptomatic cases. Antibody functions are correlated, regardless of disease severity. Longitudinal samplings show that antibody functions follow similar kinetics of induction and contraction. Overall, asymptomatic SARS-CoV-2 infection elicits polyfunctional antibodies neutralizing the virus and targeting infected cells. Twit Text FOAVip Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33899033 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33899033 #FOAvip English Wikipedia <ref>{{Cite pmid|33899033}}</ref> Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies #MMPMID33899033 Dufloo J; Grzelak L; Staropoli I; Madec Y; Tondeur L; Anna F; Pelleau S; Wiedemann A; Planchais C; Buchrieser J; Robinot R; Ungeheuer MN; Mouquet H; Charneau P; White M; Levy Y; Hoen B; Fontanet A; Schwartz O; Bruel T Cell Rep Med 2021[May]; 2 (5): 100275 PMID33899033show ga Many SARS-CoV-2-infected individuals remain asymptomatic. Little is known about the extent and quality of their antiviral humoral response. Here, we analyze antibody functions in 52 asymptomatic infected individuals, 119 mildly symptomatic, and 21 hospitalized patients with COVID-19. We measure anti-spike immunoglobulin G (IgG), IgA, and IgM levels with the S-Flow assay and map IgG-targeted epitopes with a Luminex assay. We also evaluate neutralization, complement deposition, and antibody-dependent cellular cytotoxicity (ADCC) using replication-competent SARS-CoV-2 or reporter cell systems. We show that COVID-19 sera mediate complement deposition and kill infected cells by ADCC. Sera from asymptomatic individuals neutralize the virus, activate ADCC, and trigger complement deposition. Antibody levels and functions are lower in asymptomatic individuals than they are in symptomatic cases. Antibody functions are correlated, regardless of disease severity. Longitudinal samplings show that antibody functions follow similar kinetics of induction and contraction. Overall, asymptomatic SARS-CoV-2 infection elicits polyfunctional antibodies neutralizing the virus and targeting infected cells. |Adolescent[MESH] |Adult[MESH] |Antibodies, Viral/*blood/immunology[MESH] |Antibody-Dependent Cell Cytotoxicity[MESH] |Antigen-Antibody Reactions[MESH] |Asymptomatic Diseases[MESH] |COVID-19/*pathology/virology[MESH] |Complement System Proteins/metabolism[MESH] |Epitopes/immunology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin G/blood/immunology[MESH] |Killer Cells, Natural/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Neutralization Tests[MESH] |SARS-CoV-2/isolation & purification/metabolism[MESH] |Severity of Illness Index[MESH] |Spike Glycoprotein, Coronavirus/*immunology[MESH]Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunction(epmc).pdf DeepDyve Pubget Overpricing