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10.1016/j.isci.2021.102420 http://scihub22266oqcxt.onion/10.1016/j.isci.2021.102420 33898942!8056843!33898942     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       iScience 2021 ; 24 (5): 102420 Nephropedia Template TP {{tp|p=33898942|t=2021. Cell-type-resolved quantitative proteomics map of interferon response against SARS-CoV-2 |pdf=|usr=}}{{33898942}} gab.com Text Cell-type-resolved quantitative proteomics map of interferon response against SARS-CoV-2 JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=33898942 #FOAvip The commonly used laboratory cell lines are the first line of experimental models to study the pathogenicity and performing antiviral assays for emerging viruses. Here, we assessed the tropism and cytopathogenicity of the first Swedish isolate of SARS-CoV-2 in six different human cell lines, compared their growth characteristics, and performed quantitative proteomics for the susceptible cell lines. Overall, Calu-3, Caco2, Huh7, and 293FT cell lines showed a high-to-moderate level of susceptibility to SARS-CoV-2. In Caco2 cells, the virus can achieve high titers in the absence of any prominent cytopathic effect. The protein abundance profile during SARS-CoV-2 infection revealed cell-type-specific regulation of cellular pathways. Type-I interferon signaling was identified as the common dysregulated cellular response in Caco2, Calu-3, and Huh7 cells. Together, our data show cell-type specific variability for cytopathogenicity, susceptibility, and cellular response to SARS-CoV-2 and provide important clues to guide future studies. Twit Text FOAVip Cell-type-resolved quantitative proteomics map of interferon response against SARS-CoV-2 ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=33898942 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33898942 #FOAvip English Wikipedia <ref>{{Cite pmid|33898942}}</ref> Cell-type-resolved quantitative proteomics map of interferon response against SARS-CoV-2 #MMPMID33898942 Saccon E; Chen X; Mikaeloff F; Rodriguez JE; Szekely L; Vinhas BS; Krishnan S; Byrareddy SN; Frisan T; Vegvari A; Mirazimi A; Neogi U; Gupta S iScience 2021[May]; 24 (5): 102420 PMID33898942show ga The commonly used laboratory cell lines are the first line of experimental models to study the pathogenicity and performing antiviral assays for emerging viruses. Here, we assessed the tropism and cytopathogenicity of the first Swedish isolate of SARS-CoV-2 in six different human cell lines, compared their growth characteristics, and performed quantitative proteomics for the susceptible cell lines. Overall, Calu-3, Caco2, Huh7, and 293FT cell lines showed a high-to-moderate level of susceptibility to SARS-CoV-2. In Caco2 cells, the virus can achieve high titers in the absence of any prominent cytopathic effect. The protein abundance profile during SARS-CoV-2 infection revealed cell-type-specific regulation of cellular pathways. Type-I interferon signaling was identified as the common dysregulated cellular response in Caco2, Calu-3, and Huh7 cells. Together, our data show cell-type specific variability for cytopathogenicity, susceptibility, and cellular response to SARS-CoV-2 and provide important clues to guide future studies. äCell-type-resolved quantitative proteomics map of interferon response (epmc).pdf DeepDyve Pubget Overpricing