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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Heliyon 2021 ; 7 (4): e06836 Nephropedia Template TP
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Landscape of humoral immune responses against SARS-CoV-2 in patients with COVID-19 disease and the value of antibody testing #MMPMID33898857
Mahalingam S; Peter J; Xu Z; Bordoloi D; Ho M; Kalyanaraman VS; Srinivasan A; Muthumani K
Heliyon 2021[Apr]; 7 (4): e06836 PMID33898857show ga
A new pandemic is ongoing in several parts of the world. The agent responsible is the newly emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The symptoms associated with this virus are known as the coronavirus disease-2019 (COVID-19). In this review, we summarize the published data on virus specific antibodies in hospitalized patients with COVID-19 disease, patients recovered from the disease and the individuals who are asymptomatic with SARS-CoV-2 infections. The review highlights the following: i) an adjunct role of antibody tests in the diagnosis of COVID-19 in combination with RT-PCR; ii) status of antibodies from COVID-19 convalescent patients to select donors for plasma therapy; iii) the potential confounding effects of other coronaviruses, measles, mumps and rubella in antibody testing due to homology of certain viral genes; and iv) the role of antibody testing for conducting surveillance in populations, incidence estimation, contact tracing and epidemiologic studies.