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10.1016/j.imu.2021.100578 http://scihub22266oqcxt.onion/10.1016/j.imu.2021.100578 33898733!8057924!33898733     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Inform+Med+Unlocked 2021 ; 24 (ä): 100578 Nephropedia Template TP {{tp|p=33898733|t=2021. Immunoinformatics and molecular modeling approach to design universal multi-epitope vaccine for SARS-CoV-2 |pdf=|usr=}}{{33898733}} gab.com Text Immunoinformatics and molecular modeling approach to design universal multi-epitope vaccine for SARS-CoV-2 JO: Inform Med Unlocked http://www.kidney.de/pget.php?&tw=1&pmid=33898733 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmittable and pathogenic human coronavirus that caused a pandemic situation of acute respiratory syndrome, called COVID-19, which has posed a significant threat to global health security. The aim of the present study is to computationally design an effective peptide-based multi-epitope vaccine (MEV) against SARS-CoV-2. The overall model quality of the vaccine candidate, immunogenicity, allergenicity, and physiochemical analysis have been conducted and validated. Molecular dynamics studies confirmed the stability of the candidate vaccine. The docked complexes during the simulation revealed a strong and stable binding interactions of MEV with human and mice toll-like receptors (TLR), TLR3 and TLR4. Finally, candidate vaccine codons have been optimized for their in silico cloning in E. coli expression system, to confirm increased expression. The proposed MEV can be a potential candidate against SARS-CoV-2, but experimental validation is needed to ensure its safety and immunogenicity status. Twit Text FOAVip Immunoinformatics and molecular modeling approach to design universal multi-epitope vaccine for SARS-CoV-2 ????Inform Med Unlocked http://www.kidney.de/pget.php?&tw=1&pmid=33898733 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33898733 #FOAvip English Wikipedia <ref>{{Cite pmid|33898733}}</ref> Immunoinformatics and molecular modeling approach to design universal multi-epitope vaccine for SARS-CoV-2 #MMPMID33898733 Khan MT; Islam MJ; Parihar A; Islam R; Jerin TJ; Dhote R; Ali MA; Laura FK; Halim MA Inform Med Unlocked 2021[]; 24 (ä): 100578 PMID33898733show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmittable and pathogenic human coronavirus that caused a pandemic situation of acute respiratory syndrome, called COVID-19, which has posed a significant threat to global health security. The aim of the present study is to computationally design an effective peptide-based multi-epitope vaccine (MEV) against SARS-CoV-2. The overall model quality of the vaccine candidate, immunogenicity, allergenicity, and physiochemical analysis have been conducted and validated. Molecular dynamics studies confirmed the stability of the candidate vaccine. The docked complexes during the simulation revealed a strong and stable binding interactions of MEV with human and mice toll-like receptors (TLR), TLR3 and TLR4. Finally, candidate vaccine codons have been optimized for their in silico cloning in E. coli expression system, to confirm increased expression. The proposed MEV can be a potential candidate against SARS-CoV-2, but experimental validation is needed to ensure its safety and immunogenicity status. äImmunoinformatics and molecular modeling approach to design universal (epmc).pdf DeepDyve Pubget Overpricing