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10.1182/blood.2020010218 http://scihub22266oqcxt.onion/10.1182/blood.2020010218 33895804!8079262!33895804     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood 2021 ; 138 (2): 190-198 Nephropedia Template TP {{tp|p=33895804|t=2021. Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C |pdf=|usr=}}{{33895804}} gab.com Text Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=33895804 #FOAvip Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with thrombotic complications in adults, but the incidence of COVID-19-related thrombosis in children and adolescents is unclear. Most children with acute COVID-19 have mild disease, but coagulopathy has been associated with multisystem inflammatory syndrome in children (MIS-C), a postinfectious complication. We conducted a multicenter retrospective cohort study to determine the incidence of thrombosis in children hospitalized with COVID-19 or MIS-C and evaluate associated risk factors. We classified patients into 1 of 3 groups for analysis: COVID-19, MIS-C, or asymptomatic SARS-CoV-2. Among a total of 853 admissions (COVID-19, n = 426; MIS-C, n = 138; and asymptomatic SARS-CoV-2, n = 289) in 814 patients, there were 20 patients with thrombotic events (TEs; including 1 stroke). Patients with MIS-C had the highest incidence (9 [6.5%] of 138) vs COVID-19 (9 [2.1%] of 426) or asymptomatic SARS-CoV-2 (2 [0.7%] of 289). In patients with COVID-19 or MIS-C, a majority of TEs (89%) occurred in patients age >/=12 years. Patients age >/=12 years with MIS-C had the highest rate of thrombosis at 19% (9 of 48). Notably, 71% of TEs that were not present on admission occurred despite thromboprophylaxis. Multivariable analysis identified the following as significantly associated with thrombosis: age >/=12 years, cancer, presence of a central venous catheter, and MIS-C. In patients with COVID-19 or MIS-C, hospital mortality was 2.3% (13 of 564), but it was 28% (5 of 18) in patients with TEs. Our findings may help inform pediatric thromboprophylaxis strategies. Twit Text FOAVip Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=33895804 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33895804 #FOAvip English Wikipedia <ref>{{Cite pmid|33895804}}</ref> Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C #MMPMID33895804 Whitworth H; Sartain SE; Kumar R; Armstrong K; Ballester L; Betensky M; Cohen CT; Diaz R; Diorio C; Goldenberg NA; Jaffray J; Keegan J; Malone K; Randolph AG; Rifkin-Zenenberg S; Leung WS; Sochet A; Srivaths L; Zia A; Raffini L Blood 2021[Jul]; 138 (2): 190-198 PMID33895804show ga Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with thrombotic complications in adults, but the incidence of COVID-19-related thrombosis in children and adolescents is unclear. Most children with acute COVID-19 have mild disease, but coagulopathy has been associated with multisystem inflammatory syndrome in children (MIS-C), a postinfectious complication. We conducted a multicenter retrospective cohort study to determine the incidence of thrombosis in children hospitalized with COVID-19 or MIS-C and evaluate associated risk factors. We classified patients into 1 of 3 groups for analysis: COVID-19, MIS-C, or asymptomatic SARS-CoV-2. Among a total of 853 admissions (COVID-19, n = 426; MIS-C, n = 138; and asymptomatic SARS-CoV-2, n = 289) in 814 patients, there were 20 patients with thrombotic events (TEs; including 1 stroke). Patients with MIS-C had the highest incidence (9 [6.5%] of 138) vs COVID-19 (9 [2.1%] of 426) or asymptomatic SARS-CoV-2 (2 [0.7%] of 289). In patients with COVID-19 or MIS-C, a majority of TEs (89%) occurred in patients age >/=12 years. Patients age >/=12 years with MIS-C had the highest rate of thrombosis at 19% (9 of 48). Notably, 71% of TEs that were not present on admission occurred despite thromboprophylaxis. Multivariable analysis identified the following as significantly associated with thrombosis: age >/=12 years, cancer, presence of a central venous catheter, and MIS-C. In patients with COVID-19 or MIS-C, hospital mortality was 2.3% (13 of 564), but it was 28% (5 of 18) in patients with TEs. Our findings may help inform pediatric thromboprophylaxis strategies. |Adolescent[MESH] |Adult[MESH] |Age Factors[MESH] |Anticoagulants/therapeutic use[MESH] |COVID-19/*complications/diagnosis[MESH] |Child[MESH] |Child, Preschool[MESH] |Female[MESH] |Humans[MESH] |Infant[MESH] |Male[MESH] |Retrospective Studies[MESH] |Risk Factors[MESH] |SARS-CoV-2/isolation & purification[MESH] |Systemic Inflammatory Response Syndrome/*complications/diagnosis[MESH] |Thrombosis/drug therapy/*etiology/prevention & control[MESH]Rate of thrombosis in children and adolescents hospitalized with COVID(epmc).pdf DeepDyve Pubget Overpricing