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10.1016/j.clim.2021.108733

http://scihub22266oqcxt.onion/10.1016/j.clim.2021.108733
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suck abstract from ncbi


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pmid33895357      Clin+Immunol 2021 ; 227 (ä): 108733
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  • SARS-CoV-2 proteins regulate inflammatory, thrombotic and diabetic responses in human arterial fibroblasts #MMPMID33895357
  • Freda CT; Yin W; Ghebrehiwet B; Rubenstein DA
  • Clin Immunol 2021[Jun]; 227 (ä): 108733 PMID33895357show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for many pathological processes, including altered vascular disease development, dysfunctional thrombosis and a heightened inflammatory response. However, there is limited work to determine the underlying cellular responses induced by exposure to SARS-CoV-2 structural proteins. Thus, our objective was to investigate how human arterial adventitial fibroblasts inflammation, thrombosis and diabetic disease markers are altered in response to Spike, Nucleocapsid and Membrane-Envelope proteins. We hypothesized that after a short-term exposure to SARS-CoV-2 proteins, adventitial fibroblasts would have a higher expression of inflammatory, thrombotic and diabetic proteins, which would support a mechanism for altered vascular disease progression. After incubation, the expression of gC1qR, ICAM-1, tissue factor, RAGE and GLUT-4 was significantly up-regulated. In general, the extent of expression was different for each SARS-CoV-2 protein, suggesting that SARS-CoV-2 proteins interact with cells through different mechanisms. Thus, SARS-CoV-2 protein interaction with vascular cells may regulate vascular disease responses.
  • |Aorta/cytology/metabolism[MESH]
  • |COVID-19/*immunology[MESH]
  • |Cardiovascular Diseases/complications/immunology/metabolism/*virology[MESH]
  • |Carrier Proteins/metabolism[MESH]
  • |Cell Survival/immunology/physiology[MESH]
  • |Complement System Proteins/immunology[MESH]
  • |Coronavirus Envelope Proteins/immunology[MESH]
  • |Coronavirus Nucleocapsid Proteins/immunology/metabolism[MESH]
  • |Diabetes Mellitus/metabolism/*virology[MESH]
  • |Fibroblasts/*metabolism[MESH]
  • |Glucose Transporter Type 4/metabolism[MESH]
  • |Humans[MESH]
  • |Inflammation/metabolism/virology[MESH]
  • |Intercellular Adhesion Molecule-1/metabolism[MESH]
  • |Mitochondrial Proteins/metabolism[MESH]
  • |Receptor for Advanced Glycation End Products/metabolism[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Spike Glycoprotein, Coronavirus/*immunology[MESH]


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