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10.1016/j.ajpath.2021.04.006 http://scihub22266oqcxt.onion/10.1016/j.ajpath.2021.04.006 33894177!8059259!33894177     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33894177&cmd=llinks): Failed to open stream: HTTP request failed! 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Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators |pdf=|usr=}}{{33894177}} gab.com Text Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=33894177 #FOAvip Pulmonary fibrosis (PF) can arise from unknown causes, as in idiopathic PF, or as a consequence of infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Current treatments for PF slow, but do not stop, disease progression. We report that treatment with a runt-related transcription factor 1 (RUNX1) inhibitor (Ro24-7429), previously found to be safe, although ineffective, as a Tat inhibitor in patients with HIV, robustly ameliorates lung fibrosis and inflammation in the bleomycin-induced PF mouse model. RUNX1 inhibition blunted fundamental mechanisms downstream pathologic mediators of fibrosis and inflammation, including transforming growth factor-beta1 and tumor necrosis factor-alpha, in cultured lung epithelial cells, fibroblasts, and vascular endothelial cells, indicating pleiotropic effects. RUNX1 inhibition also reduced the expression of angiotensin-converting enzyme 2 and FES Upstream Region (FURIN), host proteins critical for SARS-CoV-2 infection, in mice and in vitro. A subset of human lungs with SARS-CoV-2 infection overexpress RUNX1. These data suggest that RUNX1 inhibition via repurposing of Ro24-7429 may be beneficial for PF and to battle SARS-CoV-2, by reducing expression of viral mediators and by preventing respiratory complications. Twit Text FOAVip Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=33894177 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33894177 #FOAvip English Wikipedia <ref>{{Cite pmid|33894177}}</ref> Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators #MMPMID33894177 O'Hare M; Amarnani D; Whitmore HAB; An M; Marino C; Ramos L; Delgado-Tirado S; Hu X; Chmielewska N; Chandrahas A; Fitzek A; Heinrich F; Steurer S; Ondruschka B; Glatzel M; Krasemann S; Sepulveda-Falla D; Lagares D; Pedron J; Bushweller JH; Liu P; Arboleda-Velasquez JF; Kim LA Am J Pathol 2021[Jul]; 191 (7): 1193-1208 PMID33894177show ga Pulmonary fibrosis (PF) can arise from unknown causes, as in idiopathic PF, or as a consequence of infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Current treatments for PF slow, but do not stop, disease progression. We report that treatment with a runt-related transcription factor 1 (RUNX1) inhibitor (Ro24-7429), previously found to be safe, although ineffective, as a Tat inhibitor in patients with HIV, robustly ameliorates lung fibrosis and inflammation in the bleomycin-induced PF mouse model. RUNX1 inhibition blunted fundamental mechanisms downstream pathologic mediators of fibrosis and inflammation, including transforming growth factor-beta1 and tumor necrosis factor-alpha, in cultured lung epithelial cells, fibroblasts, and vascular endothelial cells, indicating pleiotropic effects. RUNX1 inhibition also reduced the expression of angiotensin-converting enzyme 2 and FES Upstream Region (FURIN), host proteins critical for SARS-CoV-2 infection, in mice and in vitro. A subset of human lungs with SARS-CoV-2 infection overexpress RUNX1. These data suggest that RUNX1 inhibition via repurposing of Ro24-7429 may be beneficial for PF and to battle SARS-CoV-2, by reducing expression of viral mediators and by preventing respiratory complications. |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |Animals[MESH] |Bleomycin[MESH] |COVID-19/*metabolism[MESH] |Cells, Cultured[MESH] |Core Binding Factor Alpha 2 Subunit/*antagonists & inhibitors[MESH] |Disease Models, Animal[MESH] |Epithelial Cells/drug effects/metabolism[MESH] |Female[MESH] |Furin/*metabolism[MESH] |Lung/*drug effects/metabolism/pathology[MESH] |Male[MESH] |Mice[MESH] |Pulmonary Fibrosis/chemically induced/*drug therapy/pathology[MESH]Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibro(epmc).pdf DeepDyve Pubget Overpricing