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10.1016/j.jinf.2021.04.012 http://scihub22266oqcxt.onion/10.1016/j.jinf.2021.04.012 33892014!8057690!33892014     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Infect 2021 ; 82 (6): 260-268 Nephropedia Template TP {{tp|p=33892014|t=2021. Sensitivity of SARS-CoV-2 RNA polymerase chain reaction using a clinical and radiological reference standard |pdf=|usr=}}{{33892014}} gab.com Text Sensitivity of SARS-CoV-2 RNA polymerase chain reaction using a clinical and radiological reference standard JO: J Infect http://www.kidney.de/pget.php?&tw=1&pmid=33892014 #FOAvip OBJECTIVES: Diagnostic tests for SARS-CoV-2 are important for epidemiology, clinical management, and infection control. Limitations of oro-nasopharyngeal real-time PCR sensitivity have been described based on comparisons of single tests with repeated sampling. We assessed SARS-CoV-2 PCR clinical sensitivity using a clinical and radiological reference standard. METHODS: Between March-May 2020, 2060 patients underwent thoracic imaging and SARS-CoV-2 PCR testing. Imaging was independently double- or triple-reported (if discordance) by blinded radiologists according to radiological criteria for COVID-19. We excluded asymptomatic patients and those with alternative diagnoses that could explain imaging findings. Associations with PCR-positivity were assessed with binomial logistic regression. RESULTS: 901 patients had possible/probable imaging features and clinical symptoms of COVID-19 and 429 patients met the clinical and radiological reference case definition. SARS-CoV-2 PCR sensitivity was 68% (95% confidence interval 64-73), was highest 7-8 days after symptom onset (78% (68-88)) and was lower among current smokers (adjusted odds ratio 0.23 (0.12-0.42) p < 0.001). CONCLUSIONS: In patients with clinical and imaging features of COVID-19, PCR test sensitivity was 68%, and was lower among smokers; a finding that could explain observations of lower disease incidence and that warrants further validation. PCR tests should be interpreted considering imaging, symptom duration and smoking status. Twit Text FOAVip Sensitivity of SARS-CoV-2 RNA polymerase chain reaction using a clinical and radiological reference standard ????J Infect http://www.kidney.de/pget.php?&tw=1&pmid=33892014 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33892014 #FOAvip English Wikipedia <ref>{{Cite pmid|33892014}}</ref> Sensitivity of SARS-CoV-2 RNA polymerase chain reaction using a clinical and radiological reference standard #MMPMID33892014 Stockdale AJ; Fyles F; Farrell C; Lewis J; Barr D; Haigh K; Abouyannis M; Hankinson B; Penha D; Fernando R; Wiles R; Sharma S; Santamaria N; Chindambaram V; Probert C; Ahmed MS; Cruise J; Fordham I; Hicks R; Maxwell A; Moody N; Paterson T; Stott K; Wu MS; Beadsworth M; Todd S; Joekes E J Infect 2021[Jun]; 82 (6): 260-268 PMID33892014show ga OBJECTIVES: Diagnostic tests for SARS-CoV-2 are important for epidemiology, clinical management, and infection control. Limitations of oro-nasopharyngeal real-time PCR sensitivity have been described based on comparisons of single tests with repeated sampling. We assessed SARS-CoV-2 PCR clinical sensitivity using a clinical and radiological reference standard. METHODS: Between March-May 2020, 2060 patients underwent thoracic imaging and SARS-CoV-2 PCR testing. Imaging was independently double- or triple-reported (if discordance) by blinded radiologists according to radiological criteria for COVID-19. We excluded asymptomatic patients and those with alternative diagnoses that could explain imaging findings. Associations with PCR-positivity were assessed with binomial logistic regression. RESULTS: 901 patients had possible/probable imaging features and clinical symptoms of COVID-19 and 429 patients met the clinical and radiological reference case definition. SARS-CoV-2 PCR sensitivity was 68% (95% confidence interval 64-73), was highest 7-8 days after symptom onset (78% (68-88)) and was lower among current smokers (adjusted odds ratio 0.23 (0.12-0.42) p < 0.001). CONCLUSIONS: In patients with clinical and imaging features of COVID-19, PCR test sensitivity was 68%, and was lower among smokers; a finding that could explain observations of lower disease incidence and that warrants further validation. PCR tests should be interpreted considering imaging, symptom duration and smoking status. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Diagnostic Tests, Routine[MESH] |Humans[MESH] |Polymerase Chain Reaction[MESH] |RNA, Viral[MESH] |Reference Standards[MESH]Sensitivity of SARS-CoV-2 RNA polymerase chain reaction using a clinic(epmc).pdf DeepDyve Pubget Overpricing