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10.1016/j.immuni.2021.04.003 http://scihub22266oqcxt.onion/10.1016/j.immuni.2021.04.003 33891889!8043654!33891889     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2021 ; 54 (5): 1083-1095.e7 Nephropedia Template TP {{tp|p=33891889|t=2021. Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children |pdf=|usr=}}{{33891889}} gab.com Text Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33891889 #FOAvip Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening post-infectious complication occurring unpredictably weeks after mild or asymptomatic SARS-CoV-2 infection. We profiled MIS-C, adult COVID-19, and healthy pediatric and adult individuals using single-cell RNA sequencing, flow cytometry, antigen receptor repertoire analysis, and unbiased serum proteomics, which collectively identified a signature in MIS-C patients that correlated with disease severity. Despite having no evidence of active infection, MIS-C patients had elevated S100A-family alarmins and decreased antigen presentation signatures, indicative of myeloid dysfunction. MIS-C patients showed elevated expression of cytotoxicity genes in NK and CD8(+) T cells and expansion of specific IgG-expressing plasmablasts. Clinically severe MIS-C patients displayed skewed memory T cell TCR repertoires and autoimmunity characterized by endothelium-reactive IgG. The alarmin, cytotoxicity, TCR repertoire, and plasmablast signatures we defined have potential for application in the clinic to better diagnose and potentially predict disease severity early in the course of MIS-C. Twit Text FOAVip Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33891889 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33891889 #FOAvip English Wikipedia <ref>{{Cite pmid|33891889}}</ref> Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children #MMPMID33891889 Ramaswamy A; Brodsky NN; Sumida TS; Comi M; Asashima H; Hoehn KB; Li N; Liu Y; Shah A; Ravindra NG; Bishai J; Khan A; Lau W; Sellers B; Bansal N; Guerrerio P; Unterman A; Habet V; Rice AJ; Catanzaro J; Chandnani H; Lopez M; Kaminski N; Dela Cruz CS; Tsang JS; Wang Z; Yan X; Kleinstein SH; van Dijk D; Pierce RW; Hafler DA; Lucas CL Immunity 2021[May]; 54 (5): 1083-1095.e7 PMID33891889show ga Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening post-infectious complication occurring unpredictably weeks after mild or asymptomatic SARS-CoV-2 infection. We profiled MIS-C, adult COVID-19, and healthy pediatric and adult individuals using single-cell RNA sequencing, flow cytometry, antigen receptor repertoire analysis, and unbiased serum proteomics, which collectively identified a signature in MIS-C patients that correlated with disease severity. Despite having no evidence of active infection, MIS-C patients had elevated S100A-family alarmins and decreased antigen presentation signatures, indicative of myeloid dysfunction. MIS-C patients showed elevated expression of cytotoxicity genes in NK and CD8(+) T cells and expansion of specific IgG-expressing plasmablasts. Clinically severe MIS-C patients displayed skewed memory T cell TCR repertoires and autoimmunity characterized by endothelium-reactive IgG. The alarmin, cytotoxicity, TCR repertoire, and plasmablast signatures we defined have potential for application in the clinic to better diagnose and potentially predict disease severity early in the course of MIS-C. |Adolescent[MESH] |Alarmins/immunology[MESH] |Autoantibodies/immunology[MESH] |CD8-Positive T-Lymphocytes/immunology[MESH] |COVID-19/*immunology/*pathology[MESH] |Child[MESH] |Child, Preschool[MESH] |Cytotoxicity, Immunologic/genetics[MESH] |Endothelium/immunology/pathology[MESH] |Humans[MESH] |Killer Cells, Natural/immunology[MESH] |Myeloid Cells/immunology[MESH] |Plasma Cells/immunology[MESH] |Receptors, Antigen, T-Cell/genetics/immunology[MESH] |SARS-CoV-2/*immunology[MESH] |Severity of Illness Index[MESH]Immune dysregulation and autoreactivity correlate with disease severit(epmc).pdf DeepDyve Pubget Overpricing