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10.1200/GO.20.00620

http://scihub22266oqcxt.onion/10.1200/GO.20.00620
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33891480!8162972!33891480
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suck abstract from ncbi


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pmid33891480      JCO+Glob+Oncol 2021 ; 7 (ä): 577-584
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  • Treating Acute Leukemia During the COVID-19 Pandemic in an Environment With Limited Resources: A Multicenter Experience in Four Latin American Countries #MMPMID33891480
  • Demichelis-Gomez R; Alvarado-Ibarra M; Vasquez-Chavez J; Delgado-Lopez N; Gomez-Cortes C; Espinosa-Bautista K; Cooke-Tapia A; Milan-Salvatierra A; Gomez-De Leon A; Lee-Tsai YL; Rosales-Lopez D; Cabrera-Garcia A; Amador-Medina F; Cordoba-Ramirez A; Murrieta-Alvarez I; Solis-Poblano JC; Apodaca-Chavez E; Rangel-Patino J; Alvarez-Vera JL; Arana-Luna L; De la Pena-Celaya JA; Espitia-Rios ME; Hernandez-Ruiz E; Perez-Zuniga JM; Pena-Lopez E; Gonzalez-Rivera R; Garcia-Leyva MF; Tejeda-Romero M; Cruz-Rico J; Balderas-Delgado C; Ruiz-Arguelles GJ; Gomez-Almaguer D
  • JCO Glob Oncol 2021[Apr]; 7 (ä): 577-584 PMID33891480show ga
  • PURPOSE: The COVID-19 pandemic is a colossal challenge for global health; nonetheless, specific subgroups face considerably higher risks for infection and mortality. Among patients with malignant diseases, those with hematologic neoplasms are at a higher risk for poor outcomes. The objective of this study was to register treatment modifications associated with the COVID-19 pandemic and their short-term consequences in Latin America. METHODS: Multicenter, prospective, observational, cohort study including patients older than 14 years from 14 centers in four countries (Mexico, Peru, Guatemala, and Panama) who had a confirmed diagnosis of acute leukemia, and who were undergoing active treatment since the first COVID-19 case in each country until the cutoff on July 15, 2020. RESULTS: We recruited 635 patients. Treatment modifications because of the COVID-19 pandemic were reported in 40.8% of cases. The main reason for such modifications was logistic issues (55.0%) and the most frequent modification was chemotherapy delay (42.0%). A total of 13.1% patients developed COVID-19 disease, with a mortality of 37.7%. Several factors were identified as independently associated with mortality, including a diagnosis of acute myeloid leukemia (odds ratio 2.38 [95% CI, 1.47 to 3.84]; P < .001), while the use of telemedicine was identified as a protective factor (odds ratio 0.36 [95% CI, 0.18 to 0.82]; P = .014). CONCLUSION: These results highlight the collateral damage of COVID-19 in oncology patients.
  • |Acute Disease[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/epidemiology/*prevention & control/virology[MESH]
  • |Comorbidity[MESH]
  • |Epidemics[MESH]
  • |Female[MESH]
  • |Guatemala/epidemiology[MESH]
  • |Humans[MESH]
  • |Leukemia, Myeloid/diagnosis/epidemiology/*therapy[MESH]
  • |Male[MESH]
  • |Medical Oncology/*methods[MESH]
  • |Mexico/epidemiology[MESH]
  • |Middle Aged[MESH]
  • |Panama/epidemiology[MESH]
  • |Peru/epidemiology[MESH]
  • |Prospective Studies[MESH]
  • |SARS-CoV-2/*isolation & purification/physiology[MESH]


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