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10.3389/fchem.2021.622898 http://scihub22266oqcxt.onion/10.3389/fchem.2021.622898 33889562!8056153!33889562     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Chem 2021 ; 9 (ä): 622898 Nephropedia Template TP {{tp|p=33889562|t=2021. Structural Basis of Potential Inhibitors Targeting SARS-CoV-2 Main Protease |pdf=|usr=}}{{33889562}} gab.com Text Structural Basis of Potential Inhibitors Targeting SARS-CoV-2 Main Protease JO: Front Chem http://www.kidney.de/pget.php?&tw=1&pmid=33889562 #FOAvip The Coronavirus disease-19 (COVID-19) pandemic is still devastating the world causing significant social, economic, and political chaos. Corresponding to the absence of globally approved antiviral drugs for treatment and vaccines for controlling the pandemic, the number of cases and/or mortalities are still rising. Current patient management relies on supportive treatment and the use of repurposed drugs as an indispensable option. Of a crucial role in the viral life cycle, ongoing studies are looking for potential inhibitors to the main protease (M(pro)) of severe acute respiratory syndrome Coronavirus -2 (SARS-CoV-2) to tackle the pandemic. Although promising results have been achieved in searching for drugs inhibiting the M(pro), work remains to be done on designing structure-based improved drugs. This review discusses the structural basis of potential inhibitors targeting SARS-CoV-2 M(pro), identifies gaps, and provides future directions. Further, compounds with potential M(pro) based antiviral activity are highlighted. Twit Text FOAVip Structural Basis of Potential Inhibitors Targeting SARS-CoV-2 Main Protease ????Front Chem http://www.kidney.de/pget.php?&tw=1&pmid=33889562 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33889562 #FOAvip English Wikipedia <ref>{{Cite pmid|33889562}}</ref> Structural Basis of Potential Inhibitors Targeting SARS-CoV-2 Main Protease #MMPMID33889562 Mengist HM; Dilnessa T; Jin T Front Chem 2021[]; 9 (ä): 622898 PMID33889562show ga The Coronavirus disease-19 (COVID-19) pandemic is still devastating the world causing significant social, economic, and political chaos. Corresponding to the absence of globally approved antiviral drugs for treatment and vaccines for controlling the pandemic, the number of cases and/or mortalities are still rising. Current patient management relies on supportive treatment and the use of repurposed drugs as an indispensable option. Of a crucial role in the viral life cycle, ongoing studies are looking for potential inhibitors to the main protease (M(pro)) of severe acute respiratory syndrome Coronavirus -2 (SARS-CoV-2) to tackle the pandemic. Although promising results have been achieved in searching for drugs inhibiting the M(pro), work remains to be done on designing structure-based improved drugs. This review discusses the structural basis of potential inhibitors targeting SARS-CoV-2 M(pro), identifies gaps, and provides future directions. Further, compounds with potential M(pro) based antiviral activity are highlighted. äStructural Basis of Potential Inhibitors Targeting SARS-CoV-2 Main Pro(epmc).pdf DeepDyve Pubget Overpricing