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10.1038/s41588-021-00854-7 http://scihub22266oqcxt.onion/10.1038/s41588-021-00854-7 33888907!ä!33888907 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Genet 2021 ; 53 (6): 801-808 Nephropedia Template TP {{tp|p=33888907|t=2021. Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity |pdf=|usr=}}{{33888907}} gab.com Text Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=33888907 #FOAvip COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal in others. Based on a study of 1,051,032 23andMe research participants, we report genetic and nongenetic associations with testing positive for SARS-CoV-2, respiratory symptoms and hospitalization. Using trans-ancestry genome-wide association studies, we identified a strong association between blood type and COVID-19 diagnosis, as well as a gene-rich locus on chromosome 3p21.31 that is more strongly associated with outcome severity. Hospitalization risk factors include advancing age, male sex, obesity, lower socioeconomic status, non-European ancestry and preexisting cardiometabolic conditions. While non-European ancestry was a significant risk factor for hospitalization after adjusting for sociodemographics and preexisting health conditions, we did not find evidence that these two primary genetic associations explain risk differences between populations for severe COVID-19 outcomes. Twit Text FOAVip Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=33888907 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33888907 #FOAvip English Wikipedia <ref>{{Cite pmid|33888907}}</ref> Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity #MMPMID33888907 Shelton JF; Shastri AJ; Ye C; Weldon CH; Filshtein-Sonmez T; Coker D; Symons A; Esparza-Gordillo J; Aslibekyan S; Auton A Nat Genet 2021[Jun]; 53 (6): 801-808 PMID33888907show ga COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal in others. Based on a study of 1,051,032 23andMe research participants, we report genetic and nongenetic associations with testing positive for SARS-CoV-2, respiratory symptoms and hospitalization. Using trans-ancestry genome-wide association studies, we identified a strong association between blood type and COVID-19 diagnosis, as well as a gene-rich locus on chromosome 3p21.31 that is more strongly associated with outcome severity. Hospitalization risk factors include advancing age, male sex, obesity, lower socioeconomic status, non-European ancestry and preexisting cardiometabolic conditions. While non-European ancestry was a significant risk factor for hospitalization after adjusting for sociodemographics and preexisting health conditions, we did not find evidence that these two primary genetic associations explain risk differences between populations for severe COVID-19 outcomes. |*Genetic Predisposition to Disease[MESH] |ABO Blood-Group System/genetics[MESH] |Blood Grouping and Crossmatching[MESH] |COVID-19/*genetics[MESH] |Chromosomes, Human, Pair 3[MESH] |Databases, Genetic[MESH] |Disease Susceptibility[MESH] |Female[MESH] |Galactosyltransferases/genetics[MESH] |Genome-Wide Association Study[MESH] |Hospitalization[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Patient Acuity[MESH] |Racial Groups[MESH]Trans-ancestry analysis reveals genetic and nongenetic associations wi(epmc).pdf DeepDyve Pubget Overpricing