Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1172/jci.insight.146082 http://scihub22266oqcxt.onion/10.1172/jci.insight.146082 33886507!8262283!33886507     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2021 ; 6 (10): ä Nephropedia Template TP {{tp|p=33886507|t=2021. Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus |pdf=|usr=}}{{33886507}} gab.com Text Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33886507 #FOAvip Emerging coronaviruses from zoonotic reservoirs, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have been associated with human-to-human transmission and significant morbidity and mortality. Here, we study both intradermal and intramuscular 2-dose delivery regimens of an advanced synthetic DNA vaccine candidate encoding a full-length MERS-CoV spike (S) protein, which induced potent binding and neutralizing antibodies as well as cellular immune responses in rhesus macaques. In a MERS-CoV challenge, all immunized rhesus macaques exhibited reduced clinical symptoms, lowered viral lung load, and decreased severity of pathological signs of disease compared with controls. Intradermal vaccination was dose sparing and more effective in this model at protecting animals from disease. The data support the further study of this vaccine for preventing MERS-CoV infection and transmission, including investigation of such vaccines and simplified delivery routes against emerging coronaviruses. Twit Text FOAVip Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33886507 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33886507 #FOAvip English Wikipedia <ref>{{Cite pmid|33886507}}</ref> Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus #MMPMID33886507 Patel A; Reuschel EL; Xu Z; Zaidi FI; Kim KY; Scott DP; Mendoza J; Ramos S; Stoltz R; Feldmann F; Okumura A; Meade-White K; Haddock E; Thomas T; Rosenke R; Lovaglio J; Hanley PW; Saturday G; Muthumani K; Feldmann H; Humeau LM; Broderick KE; Weiner DB JCI Insight 2021[May]; 6 (10): ä PMID33886507show ga Emerging coronaviruses from zoonotic reservoirs, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have been associated with human-to-human transmission and significant morbidity and mortality. Here, we study both intradermal and intramuscular 2-dose delivery regimens of an advanced synthetic DNA vaccine candidate encoding a full-length MERS-CoV spike (S) protein, which induced potent binding and neutralizing antibodies as well as cellular immune responses in rhesus macaques. In a MERS-CoV challenge, all immunized rhesus macaques exhibited reduced clinical symptoms, lowered viral lung load, and decreased severity of pathological signs of disease compared with controls. Intradermal vaccination was dose sparing and more effective in this model at protecting animals from disease. The data support the further study of this vaccine for preventing MERS-CoV infection and transmission, including investigation of such vaccines and simplified delivery routes against emerging coronaviruses. |Animals[MESH] |Coronavirus Infections/immunology/prevention & control/*veterinary[MESH] |Immunogenicity, Vaccine[MESH] |Injections, Intradermal[MESH] |Macaca mulatta/*immunology[MESH] |Middle East Respiratory Syndrome Coronavirus/genetics/*immunology[MESH] |Spike Glycoprotein, Coronavirus/genetics/immunology[MESH] |Vaccines, DNA/administration & dosage/genetics/*therapeutic use[MESH]Intradermal delivery of a synthetic DNA vaccine protects macaques from(epmc).pdf DeepDyve Pubget Overpricing