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10.19191/EP21.1-2.P100.044

http://scihub22266oqcxt.onion/10.19191/EP21.1-2.P100.044
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33884848!ä!33884848

suck abstract from ncbi


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pmid33884848      Epidemiol+Prev 2021 ; 45 (1-2): 100-109
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  • Sviluppo di un modello predittivo del rischio di decesso sulla base delle comorbidita in una coorte di 18 286 casi confermati di COVID-19 con almeno 40 anni d'eta #MMPMID33884848
  • Andreano A; Murtas R; Tunesi S; Gervasi F; Magnoni P; Russo AG
  • Epidemiol Prev 2021[Jan]; 45 (1-2): 100-109 PMID33884848show ga
  • OBJECTIVES: to develop a risk prediction model for 30-day mortality from COVID?19 in an Italian cohort aged 40 years or older. DESIGN: a population-based retrospective cohort study on prospectively collected data was conducted. SETTING AND PARTICIPANTS: the cohort included all swab positive cases aged 40 years older (No. 18,286) among residents in the territory of the Milan's Agency for Health Protection (ATS-MI) up to 27.04.2020. Data on comorbidities were obtained from the ATS administrative database of chronic conditions. MAIN OUTCOME MEASURES: to predict 30-day mortality risk, a multivariable logistic regression model, including age, gender, and the selected conditions, was developed following the TRIPOD guidelines. Discrimination and calibration of the model were assessed. RESULTS: after age and gender, the most important predictors of 30-day mortality were diabetes, tumour in first-line treatment, chronic heart failure, and complicated diabetes. The bootstrap-validated c-index was 0.78, which suggests that this model is useful in predicting death after COVID-19 infection in swab positive cases. The model had good discrimination (Brier score 0.13) and was well calibrated (Index of prediction accuracy of 14.8%). CONCLUSIONS: a risk prediction model for 30-day mortality in a large COVID-19 cohort aged 40 years or older was developed. In a new epidemic wave, it would help to define groups at different risk and to identify high-risk subjects to target for specific prevention and therapeutic strategies.
  • |*COVID-19/epidemiology/mortality[MESH]
  • |*Models, Statistical[MESH]
  • |*Risk Assessment/methods[MESH]
  • |Adult[MESH]
  • |Cohort Studies[MESH]
  • |Comorbidity[MESH]
  • |Humans[MESH]
  • |Italy/epidemiology[MESH]


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