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10.1111/ijcp.14257

http://scihub22266oqcxt.onion/10.1111/ijcp.14257
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33884718!8250231!33884718
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suck abstract from ncbi

pmid33884718      Int+J+Clin+Pract 2021 ; 75 (7): e14257
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  • Combined predictive performance of age and neutrophilic percentage on admission for severe novel coronavirus disease 2019 #MMPMID33884718
  • Chen Y; Zhi H; Zhang K; Zhu G; Liu L; Yan X; Cai Z; Zhao C; Hu Z
  • Int J Clin Pract 2021[Jul]; 75 (7): e14257 PMID33884718show ga
  • BACKGROUND: Novel coronavirus disease 2019 (COVID-19) poses a huge threat to the global public health. This study aimed to identify predictive indicators of severe COVID-19. METHODS: We retrospectively collected clinical data on hospital admission of all patients with severe COVID-19 and a control cohort (1:1) of gender- and hospital-matched patients with mild disease from 13 designated hospitals in the Hebei Province between 22 January and 15 April 2020. RESULTS: A total of 104 patients (52 with severe COVID-19 and 52 with mild disease) were included. Only age, fever, duration from symptom onset to confirmation, respiratory rate, percutaneous oxygen saturation (SpO(2) ) and neutrophilic percentage were independent predictors of severe COVID-19. Age and neutrophilic percentage performed best in predicting severe COVID-19, followed by SpO(2) . 'Age + neutrophilic percentage' (the sum of age and neutrophilic percentage) (area under the curve [AUC] 0.900, 95% confidence interval [CI] 0.825-0.950, P < .001) and 'age and neutrophilic percentage' (the prediction probability of age and neutrophilic percentage for severe type obtained by logistic regression analysis) (AUC 0.899, 95% CI 0.824-0.949, P < .001) had excellent predictive performance for severe type. The optimal cut-off for 'age + neutrophilic percentage' was >119.1 (sensitivity, 86.5%; specificity, 84.6%; Youden index, 0.712). CONCLUSION: The combination of age and neutrophil percentage could effectively predict severe COVID-19. The sum of age and neutrophil percentage was recommended for clinical application because of its excellent predictive value and practicability. TRAIL REGISTRATION: China Clinical Trial Registry, number ChiCTR2000030226. Registered 26 February 2020-Retrospectively registered, http://www.chictr.org.cn/showproj.aspx?proj=49855.
  • |*COVID-19[MESH]
  • |China/epidemiology[MESH]
  • |Humans[MESH]
  • |Neutrophils[MESH]
  • |Prognosis[MESH]
  • |Retrospective Studies[MESH]


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