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10.1093/nargab/lqab023 http://scihub22266oqcxt.onion/10.1093/nargab/lqab023 33884369!8046018!33884369     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       NAR+Genom+Bioinform 2021 ; 3 (2): lqab023 Nephropedia Template TP {{tp|p=33884369|t=2021. Platypus: an open-access software for integrating lymphocyte single-cell immune repertoires with transcriptomes |pdf=|usr=}}{{33884369}} gab.com Text Platypus: an open-access software for integrating lymphocyte single-cell immune repertoires with transcriptomes JO: NAR Genom Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=33884369 #FOAvip High-throughput single-cell sequencing (scSeq) technologies are revolutionizing the ability to molecularly profile B and T lymphocytes by offering the opportunity to simultaneously obtain information on adaptive immune receptor repertoires (VDJ repertoires) and transcriptomes. An integrated quantification of immune repertoire parameters, such as germline gene usage, clonal expansion, somatic hypermutation and transcriptional states opens up new possibilities for the high-resolution analysis of lymphocytes and the inference of antigen-specificity. While multiple tools now exist to investigate gene expression profiles from scSeq of transcriptomes, there is a lack of software dedicated to single-cell immune repertoires. Here, we present Platypus, an open-source software platform providing a user-friendly interface to investigate B-cell receptor and T-cell receptor repertoires from scSeq experiments. Platypus provides a framework to automate and ease the analysis of single-cell immune repertoires while also incorporating transcriptional information involving unsupervised clustering, gene expression and gene ontology. To showcase the capabilities of Platypus, we use it to analyze and visualize single-cell immune repertoires and transcriptomes from B and T cells from convalescent COVID-19 patients, revealing unique insight into the repertoire features and transcriptional profiles of clonally expanded lymphocytes. Platypus will expedite progress by facilitating the analysis of single-cell immune repertoire and transcriptome sequencing. Twit Text FOAVip Platypus: an open-access software for integrating lymphocyte single-cell immune repertoires with transcriptomes ????NAR Genom Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=33884369 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33884369 #FOAvip English Wikipedia <ref>{{Cite pmid|33884369}}</ref> Platypus: an open-access software for integrating lymphocyte single-cell immune repertoires with transcriptomes #MMPMID33884369 Yermanos A; Agrafiotis A; Kuhn R; Robbiani D; Yates J; Papadopoulou C; Han J; Sandu I; Weber C; Bieberich F; Vazquez-Lombardi R; Dounas A; Neumeier D; Oxenius A; Reddy ST NAR Genom Bioinform 2021[Jun]; 3 (2): lqab023 PMID33884369show ga High-throughput single-cell sequencing (scSeq) technologies are revolutionizing the ability to molecularly profile B and T lymphocytes by offering the opportunity to simultaneously obtain information on adaptive immune receptor repertoires (VDJ repertoires) and transcriptomes. An integrated quantification of immune repertoire parameters, such as germline gene usage, clonal expansion, somatic hypermutation and transcriptional states opens up new possibilities for the high-resolution analysis of lymphocytes and the inference of antigen-specificity. While multiple tools now exist to investigate gene expression profiles from scSeq of transcriptomes, there is a lack of software dedicated to single-cell immune repertoires. Here, we present Platypus, an open-source software platform providing a user-friendly interface to investigate B-cell receptor and T-cell receptor repertoires from scSeq experiments. Platypus provides a framework to automate and ease the analysis of single-cell immune repertoires while also incorporating transcriptional information involving unsupervised clustering, gene expression and gene ontology. To showcase the capabilities of Platypus, we use it to analyze and visualize single-cell immune repertoires and transcriptomes from B and T cells from convalescent COVID-19 patients, revealing unique insight into the repertoire features and transcriptional profiles of clonally expanded lymphocytes. Platypus will expedite progress by facilitating the analysis of single-cell immune repertoire and transcriptome sequencing. äPlatypus: an open-access software for integrating lymphocyte single-ce(epmc).pdf DeepDyve Pubget Overpricing